Jorma Toppari profile picture
Jorma
Toppari
InFLAMES Flagship
Professor, Institute of Biomedicine
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

Publications J Toppari 2018 Nov.pdf
CV_Jorma_Toppari_ 2018_Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function (2022)

Thyroid
Patyra Konrad, Löf Christoffer, Jaeschke Holger, Undeutsch Hendrik, Zheng Huifei Sophia, Tyystjärvi Sofia, Puławska Kamila, Doroszko Milena, Chruściel Marcin, Loo Britt-Marie, Kurkijärvi Riikka, Zhang Fu-Ping, Huang Chen-Che Jeff, Ohlsson Claes, Kero Andreina, Poutanen Matti, Toppari Jorma, Paschke Ralf, Rahman Nafis, Huhtaniemi Ilpo, Jääskeläinen Jarmo, Kero Jukka
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children (2022)

Pediatric Diabetes
Salami Falastin, Tamura Roy, You Lu, Lernmark Åke, Larsson Helena Elding, Lundgren Markus, Krischer Jeffrey, Ziegler Anette-Gabriele, Toppari Jorma, Veijola Riitta, Rewers Marian, Haller Michael J., Hagopian William, Akolkar Beena, Törn Carina; TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Novel Expression of Zona Pellucida 3 Protein in Normal Testis; Potential Functional Implications (2022)

Molecular and Cellular Endocrinology
Pulawska Kamila, Ponikwicka-Tyszko Donata, Lebiedzinska Weronika, Guo Peilan, Bernaczyk Piotr, Pilaszewicz-Puza Agata, Li Xiangdong, Chrusciel Marcin, Lupu Oana, Leskinen Sini, Mäkelä Juho-Antti, Toppari Jorma, Wolczynski Slawomir, Coelingh BenninkHerjan J.T., Huhtaniemi Ilpo, Rahman Nafis A.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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