Matti Poutanen profile picture
Professor, Institute of Biomedicine
InFLAMES Flagship


+358 29 450 2632
+358 50 366 0140
Kiinamyllynkatu 10

Areas of expertise

gentically modified mice
sex steroids
hormonal cancer



1987, M.Sc., Department of Biochemistry, University of Oulu, Finland

1993, Ph.D., Department of Clinical Chemistry, University of Oulu, Finland         

1997, Title of Docent (Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland   


Professor, Department of Physiology, University of Turku, and Director of Turku Center for Disease Modeling, University of Turku, Finland

Senior Scientist lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

Academy of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo Foundation, Vetenskaps Rådet, Business Finland and Industry

SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.


Research is mainly focused on sex steroid synthesis and action, with total number of citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400; average citations per article: 26.8; h-index: 46; 182 original peer-reviewed publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F. 28), Gut (I.F. 14)

 Co-founder, Forendo Pharma ltd ( focusing on hormonal therapies for endometriosis and male hypogonadism. The company has closed its investment rounds with the leading Nordic start-up investors Karolinska Development AB, Novo Seeds and Finnvera. 


Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging


Our research group has been internationally in a key position in providing evidence for the concept where the ligand concentration available for steroid hormone receptor binding is markedly regulated by the target tissue metabolism, termed intracrine steroid hormone action. The concept has proven to be essential for the growth and progression of both prostate and breast cancer. We, furthermore, have shown this concept to be valid also in premenopausal women, eg. in the endometriosis, and other medically relevant implications are expected to rise in the near future.


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AKR1D1 knockout mice develop a sex-dependent metabolic phenotype (2022)

Journal of Endocrinology
Gathercole Laura L, Nikolaou Nikolaos, Harris Shelley E, Arvaniti Anastasia, Poolman Toryn M, Hazlehurst Jonathan M, Kratschmar Denise V, Todorčević Marijana, Moolla Ahmad, Dempster Niall, Pink Ryan C, Saikali Michael F, Bentley Liz, Penning Trevor M, Ohlsson Claes, Cummins Carolyn L, Poutanen Matti, Odermatt Ales, Cox Roger D, Tomlinson Jeremy W
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Physiological levels of estradiol limit murine osteoarthritis progression (2022)

Journal of Endocrinology
Corciulo C., Scheffler J.M., Humeniuk P., Del Carpio Pons A., Stubelius A., Mentzer U.V., Drevinge C., Barrett A., Wüstenhagen S., Poutanen M., Ohlsson C., Lagerquist M.K., Islander U.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice (2022)

Nature Communications
Roa Juan, Ruiz-Cruz Miguel, Ruiz-Pino Francisco, Onieva Rocio, Vazquez Maria J., Sanchez-Tapia Maria J., Ruiz-Rodriguez Jose M., Sobrino Veronica, Barroso Alexia, Heras Violeta, Velasco Inmaculada, Perdices-Lopez Cecilia, Ohlsson Claes, Avendano Maria Soledad, Prevot Vincent, Poutanen Matti, Pinilla Leonor, Gaytan Francisco, Tena-Sempere Manuel
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice (2022)

International Journal of Molecular Sciences
Heinosalo Taija, Rytkönen Kalle T., Saarinen Niina, Järvensivu Päivi, Damdimopoulou Pauliina, Strauss Leena, Orasniemi Satu, Horshauge Petricia, Gabriel Michael, Koskimies Pasi, Ohlsson Claes, Kronqvist Pauliina, Poutanen Matti
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))