Partho Sen profile picture

Partho
Sen

Docent, Biochemistry

Areas of expertise

Machine Learning
Biomarker Discovery
R (Programming Language)
Python (Programming Language)
MATLAB
Snakemake
High Performance Computing (HPC)
Computational Biology
Bioinformatics
Mathematical Modeling,
Statistical Modeling
Statistical Data Analysis
Metabolomics
Single Cell Sequencing
Functional Genomics
Transcriptomics
Metagenomics
NGS
Proteomics
Human Genetics.

Biography

I've a 13-year background in computational biology and bioinformatics. My professional / research journey has been marked to unravel the intricacies of molecular signatures and processes in humans and microbes.

Currently specializing in precision and systems medicine, my focus centers on multiple myeloma and other cancer types. By utilization of multiomics (genomics, transcriptomics, proteomics and metabolomics) and clinical datasets, I tend to delineate cellular signatures and pathways associated with cancer, contributing to the biomarker discovery, and thereby attributing towards the cancer treatment.

My prior research has delved into diverse health conditions, including Diabetes (Type 1 & 2), Non-Alcoholic Fatty Liver Disease (NAFLD), Obesity, and Cardiovascular disease (Atherosclerosis). The overarching objective of my work is to identify molecular markers that serve as key insights into disease mechanisms and underlying pathways. Thereby, aim to formulate innovative drugs, inhibitors, and therapeutic strategies.

In addition to my proficiency in mathematical, statistical modeling and data science, I am an accomplished computer programmer; well-versed in machine learning. My passion lies in harnessing large datasets to design tools and methods that address contemporary challenges in healthcare, as well as cell and tissue biology.

I am confident that with my expertise, we can achieve significant breakthroughs in understanding and treating diseases that have hitherto posed significant challenges.

Publications

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Dynamics of gut metabolome and microbiota maturation during early life (2025)

iScience
Aatsinki, Anna-Katariina; Lamichhane, Santosh; Isokääntä, Heidi; Sen, Partho; Kråkström, Matilda; Amaral Alves, Marina; Keskitalo, Anniina; Munukka, Eveliina; Karlsson, Hasse; Perasto, Laura; Lukkarinen, Minna; Oresic, Matej; Kailanto, Henna-Maria; Karlsson, Linnea; Lahti, Leo; Dickens, Alex M.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis (2024)

Cell Reports Medicine
Sabatini, Silvia; Sen, Partho; Carli, Fabrizia; Pezzica, Samantha; Rosso, Chiara; Lembo, Erminia; Verrastro, Ornella; Daly, Ann; Govaere, Olivier; Cockell, Simon; Hyötyläinen, Tuulia; Mingrone, Geltrude; Bugianesi, Elisabetta; Anstee, Quentin M.; Orešič, Matej; Gastaldelli, Amalia
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA (2024)

Proceedings of the National Academy of Sciences of the United States of America
Andrabi, Syed Bilal Ahmad; Kalim, Ubaid Ullah; Palani, Senthil; Khan, Mohd Moin; Khan, Meraj Hasan; Fagersund, Jimmy; Orpana, Julius; Paulin, Niklas; Batkulwar, Kedar; Junttila, Sini; Buchacher, Tanja; Grönroos, Toni; Toikka, Lea; Ammunet, Tea; Sen, Partho; Orešič, Matej; Kumpulainen, Venla; Tuomisto, Johanna E. E.; Sinha, Rahul; Marson, Alexander; Rasool, Omid; Elo, Laura L.; Lahesmaa, Riitta
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )