Tapio Lönnberg profile picture

Tapio
Lönnberg

Senior Research Fellow, Turku Bioscience Centre
InFLAMES Flagship
Docent, Biotechnology
PhD
Single-cell immunogenomics research group at Turku Bioscience Centre; InFLAMES Flagship

Contact

Tykistökatu 6
20520
Turku

Links

Lab website
ORCID

Areas of expertise

Single-cell genomics
immunology

Biography

  • Phd 2012, University of Turku, supervised by Prof. Riitta Lahesmaa and Prof. Matej Orešič
  • Postdoc 2023-2016, Teichmann lab, EMBL-EBI and Wellcome Trust Sanger Institute, UK
  • Academy of Finland postdoc 2017-2020, Turku Bioscience Centre, University of Turku
  • 2021- Group Leader at InFLAMES Flagship
  • Secretary of the Finnish Society for Immunology



Teaching

  • Modern biotechnologies and bioinformatics
  • Medical biotechnology
  • Advanced Immunology


Research

Our research aims at gaining deeper understanding of cell fate decisions in the immune system. We leverage single-cell and spatial omics to explore phenotypic heterogeneity beyond the immune cell subsets defined by the expression of cell surface markers. Our current research encompasses arthritic, autoimmune and cardiovascular diseases, aiming to identify core gene modules that are associated with disease state and can be exploited for more efficient diagnosis, patient stratification, and therapies.

Publications

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Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma (2023)

Journal of Clinical Investigation
Huuhtanen Jani, Kasanen Henna, Peltola Katriina, Lönnberg Tapio, Glumoff Virpi, Brück Oscar, Dufva Olli, Peltonen Karita, Vikkula Johanna, Jokinen Emmi, Ilander Mette, Lee Moon Hee, Mäkelä Siru, Nyakas Marta, Li Bin, Hernberg Micaela, Bono Petri, Lähdesmäki Harri, Kreutzman Anna, Mustjoki Satu
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

PIM kinases regulate early human Th17 cell differentiation (2023)

Cell Reports
Buchacher Tanja, Shetty Ankitha, Koskela Saara A., Smolander Johannes, Kaukonen Riina, Sousa Antonio G. G., Junttila Sini, Laiho Asta, Rundquist Olof, Lonnberg Tapio, Marson Alexander, Rasool Omid, L. Laura, Lahesmaa Riitta
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures (2023)

American Journal of Human Genetics
Örd Tiit, Lönnberg Tapio, Nurminen Valtteri, Ravindran Aarthi, Niskanen Henri, Kiema Miika, Õunap Kadri, Maria Maleeha, Moreau Pierre R, Mishra Pashupati P, Palani Senthil, Virta Jenni, Liljenbäck Heidi, Aavik Einari, Roivainen Anne, Ylä-Herttuala Seppo, Laakkonen Johanna P, Lehtimäki Terho, Kaikkonen Minna U
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
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