Teijo
Saari
Professor, Anaesthesiology, Intensive Care
MD, PhD. Head of Department
Precise and new therapeutic possibilities to acute pain medicine.
Contact
Areas of expertise
Pain medicine
Analgesia
Modelling & Simulation
Pharmacometrics
Clinical Pharmacology
Drug-Drug-Interactions
Biography
Professor Teijo Saari (MD, PhD, University of Turku) is a specialist in anesthesiology and intensive care and cardiac anesthesia at the Turku University Hospital, Turku, Finland. Since 2004, he has been conducting research on clinical pharmacology examining the pain therapeutics and anesthetics and developing pharmacometric models for precise drug dosing. His PhD work evaluated drug-drug interactions between antimycotes and drugs used in anesthesiology and pain medicine (University of Turku, April 2005). In 2011-2013 he worked as post doctoral
fellow in University of Erlangen-Nuremberg, Germany in pharmacometric
research project: ’PEP’ – Personalized Effect-Controlled
Pharmacotherapy. Since 2013, he has lead his research group focusing on acute pain medicine. In January 2017, he was appointed to Tenure Track as Associate Professor and in June 2021 as Full Professor and Chairman of Anesthesiology and Intensive Care at the University of Turku.
His career publications total is 57 (h-index 20) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
His career publications total is 57 (h-index 20) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
Teaching
Teaching responsibilities: 1) Anesthesiology and Intensive care for medical students, 2) Graduate studies for MDs
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
Research
Professor Saari's principal research focus has been to provide novel information on therapeutics used in acute pain medicine. Beginning from 2013 he has led a research group with special interest on model-informed precision dosing and development of new dosing modalities for pain therapeutics. Important aspect of his research has been a pursuit to reduce opioid use with adjuvants added to the opioid therapy in the postoperative setting. His work has demonstrated that pharmacometric models can improve the precision of drug dosing during postoperative phase. Furthermore, his studies have established covariate effects explaining between-patient variability. His future aim is to discover biomarkers that can predict chronic pain development.
Publications
S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial (2021)
PLoS ONE
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Tulehduskipulääkkeiden vaikutusmekanismi (2021)
(Artikkeli ammatillisessa kokoomateoksessa (D2))Tulehduskipulääkkeiden kliininen käyttö (2021)
(Artikkeli ammatillisessa kokoomateoksessa (D2))Sähköisten terveyspalveluiden opetus lääketieteessä (2021)
Duodecim
(Artikkeli ammattilehdessä tai kirjoitus ammatillisessa blogissa (D1))
Anestesiologia kehittyy leikkaussalien ulkopuolella (2021)
Duodecim
(Artikkeli ammattilehdessä tai kirjoitus ammatillisessa blogissa (D1))
Deksmedetomidiinin uudet antamistavat laajentavat käyttöaiheita tehohoitosedaation ulkopuolelle (2020)
Duodecim
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))
Pharmacokinetics and Sedative Effects of Intranasal Dexmedetomidine in Ambulatory Pediatric Patients (2020)
Anesthesia and Analgesia
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions (2020)
Clinical Pharmacokinetics
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Autismikirjon potilaiden anestesia (2020)
Finnanest
(Artikkeli ammattilehdessä tai kirjoitus ammatillisessa blogissa (D1))
Cerebral autoregulation after aneurysmal subarachnoid haemorrhage. A preliminary study comparing dexmedetomidine to propofol and/or midazolam (2020)
Acta Anaesthesiologica Scandinavica
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))