Teijo
Saari
Professor, Anaesthesiology, Intensive Care
MD, PhD. Head of Department
Precise and new therapeutic possibilities to acute pain medicine.
Contact
Areas of expertise
Pain medicine
Analgesia
Modelling & Simulation
Pharmacometrics
Clinical Pharmacology
Drug-Drug-Interactions
Biography
Professor Teijo Saari (MD, PhD, University of Turku) is a specialist in anesthesiology and intensive care and cardiac anesthesia at the Turku University Hospital, Turku, Finland. Since 2004, he has been conducting research on clinical pharmacology examining the pain therapeutics and anesthetics and developing pharmacometric models for precise drug dosing. His PhD work evaluated drug-drug interactions between antimycotes and drugs used in anesthesiology and pain medicine (University of Turku, April 2005). In 2011-2013 he worked as post doctoral
fellow in University of Erlangen-Nuremberg, Germany in pharmacometric
research project: ’PEP’ – Personalized Effect-Controlled
Pharmacotherapy. Since 2013, he has lead his research group focusing on acute pain medicine. In January 2017, he was appointed to Tenure Track as Associate Professor and in June 2021 as Full Professor and Chairman of Anesthesiology and Intensive Care at the University of Turku.
His career publications total is 57 (h-index 20) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
His career publications total is 57 (h-index 20) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
Teaching
Teaching responsibilities: 1) Anesthesiology and Intensive care for medical students, 2) Graduate studies for MDs
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
Research
Professor Saari's principal research focus has been to provide novel information on therapeutics used in acute pain medicine. Beginning from 2013 he has led a research group with special interest on model-informed precision dosing and development of new dosing modalities for pain therapeutics. Important aspect of his research has been a pursuit to reduce opioid use with adjuvants added to the opioid therapy in the postoperative setting. His work has demonstrated that pharmacometric models can improve the precision of drug dosing during postoperative phase. Furthermore, his studies have established covariate effects explaining between-patient variability. His future aim is to discover biomarkers that can predict chronic pain development.
Publications
The effects of dexmedetomidine on cerebral autoregulation and cerebral oxygenation in subarachnoid haemorrhage patients (2015)
Acta Anaesthesiologica Scandinavica
(Muu (O2))
Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol (2015)
European Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Tavoiteohjattu infuusio (2015)
Spirium
(Artikkeli ammattilehdessä tai kirjoitus ammatillisessa blogissa (D1))
Population Pharmacokinetic Modeling of Hydromorphone in Cardiac Surgery Patients during Postoperative Pain Therapy. (2014)
Anesthesiology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Influence of intensive care treatment on the protein binding of sufentanil and hydromorphone during pain therapy in postoperative cardiac surgery patients. (2014)
British Journal of Anaesthesia
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction (2013)
European Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
A Semiphysiological Population Pharmacokinetic Model for Dynamic Inhibition of Liver and Gut Wall Cytochrome P450 3A by Voriconazole (2013)
Clinical Pharmacokinetics
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Rifampicin markedly decreases the exposure to oral and intravenous tramadol (2013)
European Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Does the pharmacology of oxycodone justify its increasing use as an analgesic? (2013)
Trends in Pharmacological Sciences
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))
Analysis of total and unbound hydromorphone in human plasma by ultrafiltration and LC-MS/MS: Application to clinical trial in patients undergoing open heart surgery (2012)
Journal of Pharmaceutical and Biomedical Analysis
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))