Anne Roivainen profile picture
Anne
Roivainen
Professor, Turku PET Centre
Professor, Turku PET Centre
Professor of Preclinical Imaging and Drug Research

Contact

+358 40 824 3510
Kiinamyllynkatu 4-8
20520
Turku

Areas of expertise

Molecular Imaging
PET
Inflammation Imaging

Research

http://inflammation-imaging.utu.fi

Our group is based in Turku PET Centre, University of Turku and Turku University Hospital. Our research focuses on developing radiopharmaceuticals for the PET imaging of various inflammatory diseases.

Inflammation is a significant component of several chronic diseases involving the cardiovascular, metabolic, respiratory, gastro-intestinal, musculoskeletal and nervous systems. Positron emission tomography (PET) with targeted probes enables evaluation of the molecular and cellular pathophysiological mechanisms of diseases (i.e. molecular imaging). However, more specific markers than the currently used glucose analogue, fluorodeoxyglucose 18F-FDG, are needed to assess inflammation and its consequences in different pathologies. Aims of our studies are pre-clinical evaluation of new targeted probes and techniques for molecular imaging of inflammation. The imaging agents will be evaluated in experimental models of inflammation, in healthy subjects and in patients. The main hypothesis is that sensitive whole-body imaging of inflammation will enable early diagnosis, help in patient selection to particular therapy and monitor therapy outcome. Noteworthy, the development of new radiopharmaceuticals requires several years’ effort and expensive proof-of-concept and acute toxicity studies. Our research is focusing on PET tracers and to lesser extent magnetic resonance (MR) and single-photon emission computed tomography (SPECT) imaging agents.


Publications

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[11C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue (2022)

European Journal of Nuclear Medicine and Molecular Imaging
Sun Lihua, Aarnio Richard, Herre Erika Atencio, Karna Salli, Palani Senthil, Virtanen Helena, Liljenback Heidi, Virta Jenni, Honkaniemi Aake, Oikonen Vesa, Han Chunlei, Laurila Sanna, Bucci Marco, Helin Semi, Yatkin Emrah, Nummenmaa Lauri, Nuutila Pirjo, Tang Jing, Roivainen Anne
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Comparing Folate Receptor β Targeting Tracers in Experimental Myocarditis Model (2022)

Annual Congress of European Association of Nuclear Medicine and Molecular Imaging, European Journal of Nuclear Medicine and Molecular Imaging
Atencio Herre E, Li X, Liljenbäck H, Andriana P, Jahandideh A, Iqbal I, Dillemuth P, Kärnä S, Virta J, Mansour H, Cleveland NA, Low PS, Knuuti J, Saraste A, Roivainen A
(Vertaisarvioimaton konferenssijulkaisu (B3))