Anton Zavialov profile picture
Anton
Zavialov
PhD, Head of Laboratory
Bacterial attachment, biofilm formation, and host tissue invasion. Cell-signalling mechanism of adenosine deaminase growth factor ADA2.

Contact

+358 29 450 3211
+358 50 328 6112
Arcanuminkuja 1
20500
Turku

Areas of expertise

Structural biology and structure-based drug design
X-ray crystallography
Cryo-electron microscopy
Microbiology and cell biology
Biochemistry
Protein chemistry
Protein engineering
Molecular chaperones
Secretion
Assembly.

Research

We work in the field of structural biology and structure-based drug design. Our main methods are x-ray crystallography and cryo-electron microscopy. The main focus of our research is the unraveling of molecular mechanisms governing the interplay between microbial pathogens and their hosts, and the exploitation of these finding in medicine. We are particularly interested in host-pathogen interactions during the early steps of infection: bacterial attachment and biofilm formation mediated by fimbrial adhesins and host tissue invasion mediated by the Type III secretion system. Blocking these steps could prevent infections caused by antibiotic-resistant pathogens. Another line of our research explores the intricate cell signaling mechanism of the novel growth factor-enzyme, adenosine deaminase type 2 (ADA2). This study paves the way for the development of novel means to treat blood cancers and vascular disorders, including a genetic disease called deficiency of ADA2 (DADA2). In addition, we develop a novel ADA-based immuno-oncological therapy of advanced cancers.

Publications

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A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+T cell responses (2019)

PLoS Neglected Tropical Diseases
Sakkestad S.T., Steinsland H., Skrede S., Lillebo K., Skutlaberg D.H., Guttormsen A.B., Zavialov A., Paavilainen S., Soyland H., Saevik M., Heien A.R., Tellevik M.G., Barry E., Langeland N., Sommerfelt H., Hanevik K.
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Structural basis for Acinetobacter baumannii biofilm formation (2018)

Proceedings of the National Academy of Sciences of the United States of America
Natalia Pakharukova, Minna Tuittila, Sari Paavilainen, Henri Malmi, Olena Parilova, Susann Teneberg, Stefan D. Knight, Anton V. Zavialov
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)