Deepankar Chakroborty profile picture
Deepankar
Chakroborty
Doctoral Candidate, Institute of Biomedicine
Doctoral Student, Institute of Biomedicine
MSc

Contact

+358 29 450 3786
Tykistökatu 6
20520
Turku

Areas of expertise

Epidermal Growth Factor Receptor (EGFR), EGFR family
Receptor Tyrosine Kinases
Tyrosine Kinase inhibitors
Cancer
Cancer Biology
Bioinformatics
Functional Genomics
R statistical programming
Therapeutic resistance
High -throughput screen

Biography

I am a Doctoral student in the Turku Doctoral Programme of Molecular Medicine. I have a background in biotechnology and bioinformatics. Currently, I am pursuing my PhD under the joint supervision of Prof. Klaus Elenius and Dr. Laura Elo.

Research

Efforts of functional characterization of cancer-associated somatic mutations in oncogenes have been largely incomprehensive because they do not encompass the large majority. I have developed a pipeline to analyze thousands of variants of an oncogenic kinase gene in a single assay, I call iSCREAM (in vitro SCReen for Activating Mutation). We are developing the iSCREAM workflow to preemptively identify and characterize on-target secondary mutations that can cause therapeutic resistance, and then subsequently identify therapies that would potentially work for those resistant mutations.

Publications

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L1TD1 - a prognostic marker for colon cancer (2019)

BMC Cancer
Deepankar Chakroborty, Maheswara Reddy Emani, Riku Klén, Camilla Böckelman, Jaana Hagström, Caj Haglund, Ari Ristimäki, Riitta Lahesmaa, Laura L. Elo
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)