Jorma Toppari profile picture

Jorma
Toppari

Professor, Institute of Biomedicine
InFLAMES Flagship
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

CV_Jorma_Toppari_ 2018_Nov.pdf
Publications J Toppari 2018 Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Thyroid autoimmunity and the subsequent development of islet and celiac autoimmunity in the TEDDY study (2026)

American Journal of Epidemiology
Clasen, Joanna L.; Jonsdottir, Berglind; Vehik, Kendra; Lynch, Kristian F.; Parikh, Hemang M.; Koskenniemi, Jaakko J.; Lernmark, Åke; Agardh, Daniel; Hagopian, William A.; Rewers, Marian J.; Toppari, Jorma; Ziegler, Anette-Gabriele; Akolkar, Beena; Krischer, Jeffrey P.; Haller, Michael; Elding Larsson, Helena
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Cohort Profile Update: Expanding the Cardiovascular Risk in Young Finns Study into a multigenerational cohort (2026)

International Journal of Epidemiology
Pahkala, Katja; Rovio, Suvi; Kartiosuo, Noora; Auranen, Kari; Bourgery, Matthieu; Elovainio, Marko; Fogelholm, Mikael; Haapala, Johanna; Hirvensalo, Mirja; Hutri, Nina; Jokinen, Eero; Jula, Antti; Juonala, Markus; Kaikkonen, Jari; Kiviranta, Hannu; Koskinen, Juhani S.; Kotaja, Noora; Kahonen, Mika; Laitinen, Tomi P.; Lehtimaki, Terho; Lisinen, Irina; Loo, Britt-Marie; Lyytikainen, Leo-Pekka; Magnussen, Costan G.; Mishra, Pashupati P.; Mykkanen, Juha; Makela, Juho-Antti; Mannisto, Satu; Nevalainen, Jaakko; Pulkki-Raback, Laura; Raitoharju, Emma; Rantakokko, Panu; Ronnemaa, Tapani; Stenbacka, Sini; Taittonen, Leena; Tammelin, Tuija H.; Toppari, Jorma; Tossavainen, Paivi; Viikari, Jorma; Raitakari, Olli
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Marine n-3 long-chain polyunsaturated fatty acid intake in pregnancy and risk of early life infections in three Nordic cohorts: a HEDIMED consortium study (2026)

Journal of Nutrition
Rantala, Aino K.; Hakola, Leena; Brustad, Nicklas; Tapia, German; Hård af Segerstad, Elin M.; Lehtonen, Jussi; Thorsen, Jonathan; Åkerlund, Mari; Parr, Christine L.; Magnus, Maria C.; Lund-Blix, Nicolai A.; Stokholm, Jakob; Knip, Mikael; Toppari, Jorma; Størdal, Ketil; Veijola, Riitta; Hyöty, Heikki; Virtanen, Suvi M.; Bønnelykke, Klaus; Stene, Lars C.; the HEDIMED Investigator Group
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B (2026)

eLife
Aydemir, Ozkan; Bailey, Jeffrey A.; Agardh, Daniel; Lernmark, Ake; Noble, Janelle A.; Andersson Svard, Agnes; Blankenhorn, Elizabeth P.; Parikh, Hemang M.; Ziegler, Anette-G; Toppari, Jorma; Akolkar, Beena; Hagopian, William A.; Rewers, Marian J.; Mordes, John P.; TEDDY Study Group
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

β-Cell Function and Glucose Tolerance in Persons With Multiple Islet Autoantibodies Randomized to a Gluten-free Diet (2025)

Journal of the Endocrine Society
Maziarz, Marlena; Koskenniemi, Jaakko J; Martinez, Maria Månsson; Spiliopoulos, Lampros; Salami, Falastin; Toppari, Jorma; Kero, Jukka; Veijola, Riitta; Tossavainen, Päivi; Palmu, Sauli; Aronsson, Carin Andrén; Lundgren, Markus; Borg, Henrik; Katsarou, Anastasia; Elding, Larsson Helena; Knip, Mikael; Lou, Olivia; Dunne, Jessica L; Törn, Carina; Lernmark, Åke
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
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