Jorma Toppari profile picture
Jorma
Toppari
InFLAMES Flagship
Professor, Institute of Biomedicine
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study (2022)

Nature Communications
Auchtung Thomas A., Stewart Christopher J., Smith Daniel P., Triplett Eric W., Agardh Daniel, Hagopian William A., Ziegler Anette G., Rewers Marian J., She Jin-Xiong, Toppari Jorma, Lernmark Åke, Akolkar Beena, Krischer Jeffrey P., Vehik Kendra, Auchtung Jennifer M., Ajami Nadim J., Petrosino Joseph F.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study (2022)

Scientific Reports
Törn Carina, Liu Xiang, Onengut-Gumuscu Suna, Counts Kevin M, Moreno Jose Leonardo, Remedios Cassandra L, Chen Wei-Min, LeFaive Jonathon, Butterworth Martha D, Akolkar Beena, Krischer Jeffrey P, Lernmark Åke, Rewers Marian, She Jin-Xiong, Toppari Jorma, Ziegler Anette-Gabriele, Ratan Aakrosh, Smith Albert V, Hagopian William A, Rich Stephen S, Parikh Hemang M; The TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples (2022)

Epigenetics
Laajala Essi, Halla-Aho Viivi, Grönroos Toni, Kalim Ubaid Ullah, Vähä-Mäkilä Mari, Nurmio Mirja, Kallionpää Henna, Lietzén Niina, Mykkänen Juha, Rasool Omid, Toppari Jorma, Oresic Matej, Knip Mikael, Lund Riikka, Lahesmaa Riitta, Lähdesmäki Harri
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))