Jorma Toppari profile picture
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Professor, Institute of Biomedicine


+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
type 1 diabetes


Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 


Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology


The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.


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Environmental toxicants and male fertility (2023)

Best Practice and Research: Clinical Obstetrics and Gynaecology
Rodprasert Wiwat, Toppari Jorma, Virtanen Helena E.
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))

Incidence of Pediatric Celiac Disease Varies by Region (2023)

American Journal of Gastroenterology
Stahl Marisa, Li Qian, Lynch Kristian, Koletzko Sibylle, Mehta Pooja, Gragert Loren, Norris Jill M, Andrén Aronsson Carin, Lindfors Katri, Kurppa Kalle, Ilonen Jorma, Krischer Jeffrey, Alkolkar Beena, Ziegler Anette-G, Toppari Jorma, Rewers Marian J, Agardh Daniel, Hagopian William, Liu Edwin; TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study (2023)

Diabetes Care
Thorsen Steffen U., Liu Xiang, Kataria Yachana, Mandrup-Poulsen Thomas, Kaur Simranjeet, Uusitalo Ulla, Virtanen Suvi M., Norris Jill M., Rewers Marian, Hagopian William, Yang Jimin, She Jin-Xiong, Akolkar Beena, Andrén Aronsson Carin, Lernmark Åke, Ziegler Anette-Gabriele, Toppari Jorma, Krischer Jeffrey, Parikh Hemang M., Ellervik Christina, Svensson Jannet; TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))