Jorma Toppari profile picture
Jorma
Toppari
Professor, Institute of Biomedicine
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats (2021)

Reproductive Toxicology
Alarcon Sonia, Esteban Javier, Roos Robert, Heikkinen Päivi, Sanchez-Perez Ismael, Adamsson Annika, Toppari Jorma, Koskela Antti, Finnilä Mikko AJ, Tuukkanen Juha, Herlin Maria, Hamscher Gerd, Leslie Heather A, Korkalainen Merja, Halldin Krister, Schrenk Dieter, Håkansson Helen, Viluksela Matti
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity (2021)

Scientific Reports
Niinistö S, Erlund I, Lee HS, Uusitalo U, Salminen I, Aronsson CA, Parikh HM, Liu X, Hummel S, Toppari J, She JX, Lernmark A, Ziegler AG, Rewers M, Akolkar B, Krischer JP, Galas D, Das S, Sakhanenko N, Rich SS, Hagopian W, Norris JM, Virtanen SM; the TEDDY Study Group
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study: TEFA (2021)

Endocrinology, Diabetes and Metabolism
Martinez Maria Månsson, Salami Falastin, Larsson Helena Elding, Toppari Jorma, Lernmark Åke, Kero Jukka, Veijola Riitta, Koskenniemi Jaakko J., Tossavainen Päivi, Lundgren Markus, Borg Henrik, Katsarou Anastasia, Maziarz Marlena, Törn Carina; The TEDDY Family (TEFA) Study Group
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

RANKL regulates male reproductive function (2021)

Nature Communications
Jensen MB, Andreassen CH, Jorgensen A, Nielsen JE, Mortensen L, Boisen IM, Schwarz P, Toppari J, Baron R, Lanske B, Juul A
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes (2021)

Diabetes Care
Nurminen Noora, Cerrone Damiano, Lehtonen Jussi, Parajuli Anirudra, Roslund Marja, Lonnrot Maria, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Knip Mikael, Rajaniemi Juho, Laitinen Olli H., Sinkkonen Aki, Hyöty Heikki
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)