Kaisa Huhtinen profile picture
Kaisa
Huhtinen
Project Specialist, Institute of Biomedicine
Adjunct Professor, Faculty of Medicine
PhD, Adjunct Professor in Cancer Biology

Contact

+358 29 450 2645
+358 50 572 6733
Kiinamyllynkatu 10
20520
Turku

Links

ResearchGate_Kaisa_Huhtinen
ORCID

Areas of expertise

Ovarian cancer
personalized medicine
early diagnostics
prediction
prognosis
biomarker
genomics
drug target
interdicipline research;

Biography

2018 Starting as an independent group leader
2016 Adjunct Professor, Cancer Biology, University of Turku
2014 Cell biologist (4 months), Turku University Hospital
2012- Postdoctoral fellow / Senior researcher in Olli Carpén research group, Univ. Turku
2010-2012 Postdoctoral fellow in the ENDOMET study, Prof. Matti Poutanen group, Univ. Turku
2010 Ph.D., Departments of Physiology and Obstetrics & Gynecology, University of Turku

Research

I am interested in understanding molecular mechanisms behind high-grade serous ovarian cancer, which is the most lethal type of epithelial ovarian cancer. Our reseach focuses on two main themes: genomic alterations such as gene fusions and development of innovative diagnostic tools. Our ultimate aim is to improve patient survival by 1) developing biomarkers / marker panels for early detection of HGSOC, 2) finding predictive markers enabling personalized therapies, and 3) characterizing new potential drug targets for personalized HGSOC treatment.

Publications

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Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype (2022)

Molecular Cancer Therapeutics
Cvrljevic Anna N. Butt Umar, Huhtinen Kaisa, Grönroos Tove J., Böckelman Camilla, Lassus Heini, Butzow Ralf, Haglund Caj, Kaipio Katja, Arsiola Tiina, Laajala Teemu D., Connolly Denise C, Ristimäki Ari, Carpen Olli, Pouwels Jeroen, Westermarck Jukka
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Dubious effects of methadone as an “anticancer” drug on ovarian cancer cell-lines and patient-derived tumor-spheroids (2022)

Gynecologic Oncology
Fiegl Heidelinde, Hagenbuchner Judith, Kyvelidou Christiana, Seeber Beata, Sopper Sieghart, Tsibulak Irina, Wieser Verena, Reiser Elisabeth, Roessler Julia, Huhtinen Kaisa, Carpén Olli, Parson Walther, Sprung Susanne, Marth Christian, Ausserlechner Michael J., Zeimet Alain G.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status (2022)

Frontiers in Oncology
Roering Pia, Siddiqui Arafat, Heuser Vanina D, Potdar Swapnil, Mikkonen Pia, Oikkonen Jaana, Li Yilin, Pikkusaari Sanna, Wennerberg Krister, Hynninen Johanna, Grenman Seija, Huhtinen Kaisa, Auranen Annika, Carpén Olli, Kaipio Katja
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer (2022)

Science Advances
Zhang Kaiyang, Erkan Erdogan Pekcan, Jamalzadeh Sanaz, Dai Jun, Andersson Noora, Kaipio Katja, Lamminen Tarja, Mansuri Naziha, Huhtinen Kaisa, Carpén Olli, Hietanen Sakari, Oikkonen Jaana, Hynninen Johanna, Virtanen Anni, Häkkinen Antti, Hautaniemi Sampsa, Vähärautio Anna
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

FUNGI: Fusion Gene Integration Toolset (2021)

Bioinformatics
Cervera Alejandra, Rausio Heidi, Kähkönen Tiia, Andersson Noora, Partel Gabriele, Rantanen Ville, Paciello Giulia, Ficarra Elisa, Hynninen Johanna, Hietanen Sakari, Carpén Olli, Lehtonen Rainer, Hautaniemi Sampsa, Huhtinen Kaisa
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer (2021)

Briefings in Bioinformatics
He Liye, Bulanova Daria, Oikkonen Jaana, Häkkinen Antti, Zhang Kaiyang, Zheng Shuyu, Wang Wenyu, Erkan Erdogan Pekcan, Carpén Olli, Joutsiniemi Titta, Hietanen Sakari, Hynninen Johanna, Huhtinen Kaisa, Hautaniemi Sampsa, Vähärautio Anna, Tang Jing, Wennerberg Krister, Aittokallio Tero
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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