Kaisa Huhtinen profile picture
Kaisa
Huhtinen
Senior Researcher, Institute of Biomedicine
Adjunct Professor, Faculty of Medicine
PhD, Adjunct Professor in Cancer Biology

Contact

+358 29 450 2645
+358 50 572 6733
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Ovarian cancer
personalized medicine
early diagnostics
prediction
prognosis
biomarker
genomics
drug target
interdicipline research;

Biography

2018 Starting as an independent group leader
2016 Adjunct Professor, Cancer Biology, University of Turku
2014 Cell biologist (4 months), Turku University Hospital
2012- Postdoctoral fellow / Senior researcher in Olli Carpén research group, Univ. Turku
2010-2012 Postdoctoral fellow in the ENDOMET study, Prof. Matti Poutanen group, Univ. Turku
2010 Ph.D., Departments of Physiology and Obstetrics & Gynecology, University of Turku

Research

I am interested in understanding molecular mechanisms behind high-grade serous ovarian cancer, which is the most lethal type of epithelial ovarian cancer. Our reseach focuses on two main themes: genomic alterations such as gene fusions and development of innovative diagnostic tools. Our ultimate aim is to improve patient survival by 1) developing biomarkers / marker panels for early detection of HGSOC, 2) finding predictive markers enabling personalized therapies, and 3) characterizing new potential drug targets for personalized HGSOC treatment.

Publications

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ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors (2020)

Journal of Pathology
Katja Kaipio, Ping Chen, Pia Roering, Kaisa Huhtinen, Piia Mikkonen, Päivi Östling, Laura Lehtinen, Naziha Mansuri, Taina Korpela, Swapnil Potdar, Johanna Hynninen, Annika Auranen, Seija Grénman, Krister Wennerberg, Sampsa Hautaniemi, Olli Carpén
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy (2020)

Cancer Discovery
Sonia Iyer, Shuang Zhang, Simge Yucel, Heiko Horn, Sean G Smith, Ferenc Reinhardt, Esmee Hoefsmit, Bimarzhan Assatova, Julia Casado, Marie-Charlotte Meinsohn, M Inmaculada Barrasa, George W Bell, Fernando Perez-Villatoro, Kaisa Huhtinen, Johanna Hynninen, Jaana Oikkonen, Pamoda M Galhenage, Shailja Pathania, Paula T Hammond, Benjamin G Neel, Anniina Färkkilä, David Pépin, Robert A. Weinberg
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)