
Klaus
Elenius
Professor, Institute of Biomedicine
MD, PhD, professor
Research
ACTIONABLE RECEPTOR TYROSINE KINASE SIGNALING
Our goal is to understand how receptor tyrosine kinases (RTK) regulate the pathogenesis of human diseases, such as cancer. This information is needed for the development of molecularly targeted therapies. To recognize aberrations of RTK signaling in diseased tissue our laboratory also works on the molecular mechanism by which RTKs control normal processes, such as embryonic development. The work mainly focuses on the ErbB family of RTKs. Our laboratory has contributed to the field by e.g. by characterizing novel RTK signaling mechanisms, by identifying novel ErbB4 isoforms, and by determining the role of ErbBs and their ligands in angiogenesis.
Current topics
- Screens for predictive RTK mutations
- Novel RTK signaling mechanisms
- Development of preclinical models for development novel RTK inhibitors
- Sequencing of RTK inhibitor drug administration with cytotoxic agents
- In vitro “basket trials” with ErbB inhibitor drugs
- RTK signaling in angiogenesis and cardiovascular diseases
- RTKs in pediatric malignancies
- Biological role of novel ErbB4 isoforms in diseases and development
Elenius Lab members
- Anne Jokilammi, PhD
- Elli Narvi, PhD
- Deepankar Chakroborty, MSc
- Juho Heliste, MD
- Marika Koivu, MSc
- Johannes Merilahti, MSc
- Veera Ojala, MSc
- Janne Nordberg, MD
- Fred Saarinen, MSc
- Katri Vaparanta, MSc
- Kaisa Aalto, BM
- Maria Helkkula, BM
- Matias Mäenpää, BM
- Peppi Kirjalainen, BM
- Jori Torkkila, BM
Publications
An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease (2021)
European Journal of Human Genetics
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Erbb4 regulates the oocyte microenvironment during folliculogenesis (2020)
Human Molecular Genetics
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling (2020)
American Journal of Human Genetics
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health (2020)
European Respiratory Journal
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Suomen Lääketieteen Säätiö on kulkenut lääketieteen tutkimuksen rinnalla jo 60 vuotta (2020)
Duodecim
(D1 Artikkeli ammattilehdessä)
Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases (2020)
Molecular Cancer Therapeutics
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan (2020)
Nature Medicine
(B1 Kirjoitus tieteellisessä aikakauslehdessä)
The role of polygenic risk and susceptibility genes in breast cancer over the course of life (2020)
Nature Communications
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers (2020)
Nature Medicine
(B1 Kirjoitus tieteellisessä aikakauslehdessä)
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020)
Nature
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)