Klaus Elenius profile picture
Klaus
Elenius
Professor, Institute of Biomedicine
MD, PhD, professor

Contact

+358 29 450 4393
+358 50 514 2307
Tykistökatu 6 A
20520
Turku

Research


ACTIONABLE RECEPTOR TYROSINE KINASE SIGNALING

Our goal is to understand how receptor tyrosine kinases (RTK) regulate the pathogenesis of human diseases, such as cancer. This information is needed for the development of molecularly targeted therapies. To recognize aberrations of RTK signaling in diseased tissue our laboratory also works on the molecular mechanism by which RTKs control normal processes, such as embryonic development. The work mainly focuses on the ErbB family of RTKs. Our laboratory has contributed to the field by e.g. by characterizing novel RTK signaling mechanisms, by identifying novel ErbB4 isoforms, and by determining the role of ErbBs and their ligands in angiogenesis.

Current topics

  • Screens for predictive RTK mutations
  • Novel RTK signaling mechanisms
  • Development of preclinical models for development novel RTK inhibitors
  • Sequencing of RTK inhibitor drug administration with cytotoxic agents
  • In vitro “basket trials” with ErbB inhibitor drugs
  • RTK signaling in angiogenesis and cardiovascular diseases
  • RTKs in pediatric malignancies
  • Biological role of novel ErbB4 isoforms in diseases and development

Elenius Lab members

  • Anne Jokilammi, PhD
  • Elli Narvi, PhD
  • Deepankar Chakroborty, MSc
  • Juho Heliste, MD
  • Marika Koivu, MSc 
  • Johannes Merilahti, MSc
  • Veera Ojala, MSc
  • Janne Nordberg, MD
  • Fred Saarinen, MSc
  • Katri Vaparanta, MSc
  • Kaisa Aalto, BM
  • Maria Helkkula, BM
  • Matias Mäenpää, BM
  • Peppi Kirjalainen, BM
  • Jori Torkkila, BM

Publications

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Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020)

Nature
Erik L. Bao, Satish K. Nandakumar, Xiaotian Liao, Alexander G. Bick, Juha Karjalainen, Marcin Tabaka, Olga I. Gan, Aki S. Havulinna, Tuomo T. J. Kiiskinen, Caleb A. Lareau, Aitzkoa L. de Lapuente Portilla, Bo Li, Connor Emdin, Veryan Codd, Christopher P. Nelson, Christopher J. Walker, Claire Churchhouse, Albert de la Chapelle, Daryl E. Klein, Björn Nilsson, Peter W. F. Wilson, Kelly Cho, Saiju Pyarajan, J. Michael Gaziano, Nilesh J. Samani, Aviv Regev, Aarno Palotie, Benjamin M. Neale, John E. Dick, Pradeep Natarajan, Christopher J. O’Donnell, Mark J. Daly, Michael Milyavsky, Sekar Kathiresan, Vijay G. Sankaran; FinnGen; 23andMe Research Team
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)