Klaus Elenius profile picture
Klaus
Elenius
Professor, Institute of Biomedicine
Director, BioCity Turku
Turku Bioscience Centre
MD, PhD, professor

Contact

+358 29 450 4393
+358 50 514 2307
Tykistökatu 6 A
20520
Turku

Research


ACTIONABLE RECEPTOR TYROSINE KINASE SIGNALING

Our goal is to understand how receptor tyrosine kinases (RTK) regulate the pathogenesis of human diseases, such as cancer. This information is needed for the development of molecularly targeted therapies. To recognize aberrations of RTK signaling in diseased tissue our laboratory also works on the molecular mechanism by which RTKs control normal processes, such as embryonic development. The work mainly focuses on the ErbB family of RTKs. Our laboratory has contributed to the field by e.g. by characterizing novel RTK signaling mechanisms, by identifying novel ErbB4 isoforms, and by determining the role of ErbBs and their ligands in angiogenesis.

Current topics

  • Screens for predictive RTK mutations
  • Novel RTK signaling mechanisms
  • Development of preclinical models for development novel RTK inhibitors
  • Sequencing of RTK inhibitor drug administration with cytotoxic agents
  • In vitro “basket trials” with ErbB inhibitor drugs
  • RTK signaling in angiogenesis and cardiovascular diseases
  • RTKs in pediatric malignancies
  • Biological role of novel ErbB4 isoforms in diseases and development

Elenius Lab members

  • Anne Jokilammi, PhD
  • Elli Narvi, PhD
  • Deepankar Chakroborty, MSc
  • Juho Heliste, MD
  • Marika Koivu, MSc 
  • Johannes Merilahti, MSc
  • Veera Ojala, MSc
  • Janne Nordberg, MD
  • Fred Saarinen, MSc
  • Katri Vaparanta, MSc
  • Kaisa Aalto, BM
  • Maria Helkkula, BM
  • Matias Mäenpää, BM
  • Peppi Kirjalainen, BM
  • Jori Torkkila, BM

Publications

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Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries (2021)

Nature Communications
Gharahkhani Puya, Jorgenson Eric, Hysi Pirro, Khawaja Anthony P., Pendergrass Sarah, Han Xikun, Ong Jue Sheng, Hewitt Alex W., Segrè Ayellet V., Rouhana John M., Hamel Andrew R., Igo Jr Robert P., Choquet Helene, Qassim Ayub, Josyula Navya S., Bailey Jessica N. Cooke, Bonnemaijer Pieter W. M., Iglesias Adriana, Siggs Owen M., Young Terri L., Vitart Veronique, Thiadens Alberta A. H. J., Karjalainen Juha, Uebe Steffen, Melles Ronald B., Nair K. Saidas, Luben Robert, Simcoe Mark, Amersinghe Nishani, Cree Angela J., Hohn Rene, Poplawski Alicia, Chen Li Jia, Rong Shi-Song, Aung Tin, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Tamiya Gen, Shiga Yukihiro, Yamamoto Masayuki, Nakazawa Toru, Currant Hannah, Birney Ewan, Wang Xin, Auton Adam, Lupton Michelle K., Martin Nicholas G., Ashaye Adeyinka, Olawoye Olusola, Williams Susan E., Akafo Stephen, Ramsay Michele, Hashimoto Kazuki, Kamatani Yoichiro, Akiyama Masato, Momozawa Yukihide, Foster Paul J., Khaw Peng T., Morgan James E., Strouthidis Nicholas G., Kraft Peter, Kang Jae H., Pang Chi Pui, Pasutto Francesca, Mitchell Paul, Lotery Andrew J., Palotie Aarno, van Duijn Cornelia, Haines Jonathan L., Hammond Chris, Pasquale Louis R., Klaver Caroline C. W., Hauser Michael, Khor Chiea Chuen, Mackey David A., Kubo Michiaki, Cheng Ching-Yu, Craig Jamie E., MacGregor Stuart, Wiggs Janey L.; FinnGen Study
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection (2021)

Nature Medicine
Zekavat Seyedeh M., Lin Shu-Hong, Bick Alexander G., Liu Aoxing, Paruchuri Kaavya, Wang Chen, Uddin Md Mesbah, Ye Yixuan, Yu Zhaolong, Liu Xiaoxi, Kamatani Yoichiro, Bhattacharya Romit, Pirruccello James P., Pampana Akhil, Loh Po-Ru, Kohli Puja, McCarroll Steven A., Kiryluk Krzysztof, Neale Benjamin, Ionita-Laza Iuliana, Engels Eric A., Brown Derek W., Smoller Jordan W., Green Robert, Karlson Elizabeth W., Lebo Matthew, Ellinor Patrick T., Weiss Scott T., Daly Mark J., The Biobank Japan Project, Terao Chikashi, Zhao Hongyu, Ebert Benjamin L., Reilly Muredach P., Ganna Andrea, Machiela Mitchell J., Genovese Giulio, Natarajan Pradeep; FinnGen Consortium
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

The impact of non-additive genetic associations on age-related complex diseases (2021)

Nature Communications
Guindo-Martinez Marta, Amela Ramon, Bonàs-Guarch Silvia, Puiggros Montserrat, Salvoro Cecilia, Miguel-Escalada Irene, Carey Caitlin E, Cole Joanne B, Rüeger Sina, Atkinson Elizabeth, Leong Aaron, Sanchez Friman, Ramon-Cortes Cristian, Ejarque Jorge, Palmer Duncan S, Kurki Mitja, Aragam Krishna, Florez Jose C, Badia Rosa M, Mercader Josep M, Torrents David; FinnGen
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices (2021)

Nature Communications
Natarajan Pradeep, Pampana Akhil, Graham Sarah E., Ruotsalainen Sanni E., Perry James A., de Vries Paul S., Broome Jai G., Pirruccello James P., Honigberg Michael C., Aragam Krishna, Wolford Brooke, Brody Jennifer A., Antonacci-Fulton Lucinda, Arden Moscati, Aslibekyan Stella, Assimes Themistocles L., Ballantyne Christie M., Bielak Lawrence F., Bis Joshua C., Cade Brian E., Do Ron, Doddapaneni Harsha, Emery Leslie S., Hung Yi-Jen, Irvin Marguerite R., Khan Alyna T., Lange Leslie, Lee Jiwon, Lemaitre Rozenn N., Martin Lisa W., Metcalf Ginger, Montasser May E., Moon Jee-Young, Muzny Donna, O’Connell Jeffrey R., Palmer Nicholette D., Peralta Juan M., Peyser Patricia A., Stilp Adrienne M., Tsai Michael, Wang Fei Fei, Weeks Daniel E., Yanek Lisa R., Wilson James G., Abecasis Goncalo, Arnett Donna K., Becker Lewis C., Blangero John, Boerwinkle Eric, Bowden Donald W., Chang Yi-Cheng, Chen Yii-Der I., Choi Won Jung, Correa Adolfo, Curran Joanne E., Daly Mark J., Dutcher Susan K., Ellinor Patrick T., Fornage Myriam, Freedman Barry I., Gabriel Stacey, Germer Soren, Gibbs Richard A., He Jiang, Hveem Kristian, Jarvik Gail P., Kaplan Robert C., Kardia Sharon L. R., Kenny Eimear, Kim Ryan W., Kooperberg Charles, Laurie Cathy C., Lee Seonwook, Lloyd-Jones Don M., Loos Ruth J. F., Lubitz Steven A., Mathias Rasika A., Martinez Karine A. Viaud, McGarvey Stephen T., Mitchell Braxton D., Nickerson Deborah A., North Kari E., Palotie Aarno, Park Cheol Joo, Psaty Bruce M., Rao D. C., Redline Susan, Reiner Alexander P., Seo Daekwan, Seo Jeong-Sun, Smith Albert V., Tracy Russell P., Vasan Ramachandran S., Kathiresan Sekar, Cupples L. Adrienne, Rotter Jerome I., Morrison Alanna C., Rich Stephen S., Ripatti Samuli, Willer Cristen; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; FinnGen, Peloso Gina M.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))