Klaus Elenius profile picture
Klaus
Elenius
Professor, Institute of Biomedicine
Director, BioCity Turku
Turku Bioscience Centre
MD, PhD, professor

Contact

+358 29 450 4393
+358 50 514 2307
Tykistökatu 6 A
20520
Turku

Links

Elenius Lab
Elenius Lab Tools
ORCID

Research


ACTIONABLE RECEPTOR TYROSINE KINASE SIGNALING

Our goal is to understand how receptor tyrosine kinases (RTK) regulate the pathogenesis of human diseases, such as cancer. This information is needed for the development of molecularly targeted therapies. To recognize aberrations of RTK signaling in diseased tissue our laboratory also works on the molecular mechanism by which RTKs control normal processes, such as embryonic development. The work mainly focuses on the ErbB family of RTKs. Our laboratory has contributed to the field by e.g. by characterizing novel RTK signaling mechanisms, by identifying novel ErbB4 isoforms, and by determining the role of ErbBs and their ligands in angiogenesis.

Current topics

  • Screens for predictive RTK mutations
  • Novel RTK signaling mechanisms
  • Development of preclinical models for development novel RTK inhibitors
  • Sequencing of RTK inhibitor drug administration with cytotoxic agents
  • In vitro “basket trials” with ErbB inhibitor drugs
  • RTK signaling in angiogenesis and cardiovascular diseases
  • RTKs in pediatric malignancies
  • Biological role of novel ErbB4 isoforms in diseases and development

Elenius Lab members

  • Anne Jokilammi, PhD
  • Elli Narvi, PhD
  • Deepankar Chakroborty, MSc
  • Juho Heliste, MD
  • Marika Koivu, MSc 
  • Johannes Merilahti, MSc
  • Veera Ojala, MSc
  • Janne Nordberg, MD
  • Fred Saarinen, MSc
  • Katri Vaparanta, MSc
  • Kaisa Aalto, BM
  • Maria Helkkula, BM
  • Matias Mäenpää, BM
  • Peppi Kirjalainen, BM
  • Jori Torkkila, BM

Publications

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The impact of non-additive genetic associations on age-related complex diseases (2021)

Nature Communications
Guindo-Martinez Marta, Amela Ramon, Bonàs-Guarch Silvia, Puiggros Montserrat, Salvoro Cecilia, Miguel-Escalada Irene, Carey Caitlin E, Cole Joanne B, Rüeger Sina, Atkinson Elizabeth, Leong Aaron, Sanchez Friman, Ramon-Cortes Cristian, Ejarque Jorge, Palmer Duncan S, Kurki Mitja, Aragam Krishna, Florez Jose C, Badia Rosa M, Mercader Josep M, Torrents David; FinnGen
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices (2021)

Nature Communications
Natarajan Pradeep, Pampana Akhil, Graham Sarah E., Ruotsalainen Sanni E., Perry James A., de Vries Paul S., Broome Jai G., Pirruccello James P., Honigberg Michael C., Aragam Krishna, Wolford Brooke, Brody Jennifer A., Antonacci-Fulton Lucinda, Arden Moscati, Aslibekyan Stella, Assimes Themistocles L., Ballantyne Christie M., Bielak Lawrence F., Bis Joshua C., Cade Brian E., Do Ron, Doddapaneni Harsha, Emery Leslie S., Hung Yi-Jen, Irvin Marguerite R., Khan Alyna T., Lange Leslie, Lee Jiwon, Lemaitre Rozenn N., Martin Lisa W., Metcalf Ginger, Montasser May E., Moon Jee-Young, Muzny Donna, O’Connell Jeffrey R., Palmer Nicholette D., Peralta Juan M., Peyser Patricia A., Stilp Adrienne M., Tsai Michael, Wang Fei Fei, Weeks Daniel E., Yanek Lisa R., Wilson James G., Abecasis Goncalo, Arnett Donna K., Becker Lewis C., Blangero John, Boerwinkle Eric, Bowden Donald W., Chang Yi-Cheng, Chen Yii-Der I., Choi Won Jung, Correa Adolfo, Curran Joanne E., Daly Mark J., Dutcher Susan K., Ellinor Patrick T., Fornage Myriam, Freedman Barry I., Gabriel Stacey, Germer Soren, Gibbs Richard A., He Jiang, Hveem Kristian, Jarvik Gail P., Kaplan Robert C., Kardia Sharon L. R., Kenny Eimear, Kim Ryan W., Kooperberg Charles, Laurie Cathy C., Lee Seonwook, Lloyd-Jones Don M., Loos Ruth J. F., Lubitz Steven A., Mathias Rasika A., Martinez Karine A. Viaud, McGarvey Stephen T., Mitchell Braxton D., Nickerson Deborah A., North Kari E., Palotie Aarno, Park Cheol Joo, Psaty Bruce M., Rao D. C., Redline Susan, Reiner Alexander P., Seo Daekwan, Seo Jeong-Sun, Smith Albert V., Tracy Russell P., Vasan Ramachandran S., Kathiresan Sekar, Cupples L. Adrienne, Rotter Jerome I., Morrison Alanna C., Rich Stephen S., Ripatti Samuli, Willer Cristen; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; FinnGen, Peloso Gina M.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Genomic prediction of alcohol-related morbidity and mortality (2020)

Translational Psychiatry
Kiiskinen T, Mars NJ, Palviainen T, Koskela J, Ramo JT, Ripatti P, Ruotsalainen S, Palotie A, Madden PAF, Rose RJ, Kaprio J, Salomaa V, Makela P, Havulinna AS, Ripatti S
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling (2020)

American Journal of Human Genetics
Rodriguez Benjamin AT, Bhan Arunoday, Beswick Andrew, Elwood Peter C, Niiranen Teemu J, Salomaa Veikko, Tregouet David-Alexandre, Morange Pierre-Emmanuel, Civelek Mete, Ben-Shlomo Yoav, Schlaeger Thorsten, Chen Ming-Huei, Johnson Andrew D; FinnGen Study
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Polygenic Hyperlipidemias and Coronary Artery Disease Risk (2020)

Circulation: Genomic and Precision Medicine
Ripatti P, Ramo JT, Mars NJ, Fu Y, Lin JK, Soderlund S, Benner C, Surakka I, Kiiskinen T, Havulinna AS, Palta P, Freimer NB, Widen E, Salomaa V, Tukiainen T, Pirinen M, Palotie A, Taskinen MR, Ripatti S; and on behalf of FinnGen
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health (2020)

European Respiratory Journal
Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, Kurki M, Mars N, Havulinna AS, Luonsi E, Mansour Aly D, Ahlqvist E, Teder-Laving M, Palta P, Groop L, Mäkitie A, Mägi R, Bachour A, Salomaa V, Palotie A, Tuomi T, Ripatti S, Palotie T, Ripatti S; FinnGen research group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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