Matej Oresic profile picture

Matej
Oresic

Professor, Turku Bioscience Centre
InFLAMES Flagship
Ph.D.

Contact

+358 29 450 3798
+358 46 923 3395
Tykistökatu 6
20520
Turku

Areas of expertise

Systems biology
exposome
bioinformatics
metabolomics
lipidomics
biophysics
systems medicine
computational biology

Biography

Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.

Research

Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.

Publications

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Dynamics of gut metabolome and microbiota maturation during early life (2025)

iScience
Aatsinki, Anna-Katariina; Lamichhane, Santosh; Isokääntä, Heidi; Sen, Partho; Kråkström, Matilda; Amaral Alves, Marina; Keskitalo, Anniina; Munukka, Eveliina; Karlsson, Hasse; Perasto, Laura; Lukkarinen, Minna; Oresic, Matej; Kailanto, Henna-Maria; Karlsson, Linnea; Lahti, Leo; Dickens, Alex M.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Intra- and inter-individual variation of the human lipidome (2025)

Trends in Analytical Chemistry
Anh, Nguyen Hoang; Beyene, Habtamu B.; Mocciaro, Gabriele; Hahnefeld, Lisa; Lamichhane, Santosh; Fabritius, Mikael; Avela, Henri; Wang, Yuqin; Dickens, Alex M.; Gurke, Robert; Yang, Baoru; Griffiths, William J.; Hyötyläinen, Tuulia; Meikle, Peter J.; Orešič, Matej
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)

Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study (2025)

The Lancet Planetary Health
Barron, Aaron; Dickens, Alex M; Tuulari, Jetro J; Hyötylainen, Tuulia; Kortesluoma, Susanna; Merisaari, Harri; Pulli, Elmo P; Silver, Eero; Kumpulainen, Venla; Copeland, Anni; Saukko, Ekaterina; Lewis, John D; Karlsson, Linnea; Orešič, Matej; Karlsson, Hasse
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial (2025)

Neuropsychopharmacology
Chesney, Edward; Oliver, Dominic; Sarma, Ananya; Lamper, Ayse Doga; Slimani, Ikram; Lloyd, Millie; Dickens, Alex M.; Welds, Michael; Kråkström, Matilda; Gasparini-Andre, Irma; Oresic, Matej; Lawn, Will; Babayeva, Natavan; Freeman, Tom P.; Englund, Amir; Strang, John; McGuire, Philip
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA (2024)

Proceedings of the National Academy of Sciences of the United States of America
Andrabi, Syed Bilal Ahmad; Kalim, Ubaid Ullah; Palani, Senthil; Khan, Mohd Moin; Khan, Meraj Hasan; Fagersund, Jimmy; Orpana, Julius; Paulin, Niklas; Batkulwar, Kedar; Junttila, Sini; Buchacher, Tanja; Grönroos, Toni; Toikka, Lea; Ammunet, Tea; Sen, Partho; Orešič, Matej; Kumpulainen, Venla; Tuomisto, Johanna E. E.; Sinha, Rahul; Marson, Alexander; Rasool, Omid; Elo, Laura L.; Lahesmaa, Riitta
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis (2024)

Cell Reports Medicine
Sabatini, Silvia; Sen, Partho; Carli, Fabrizia; Pezzica, Samantha; Rosso, Chiara; Lembo, Erminia; Verrastro, Ornella; Daly, Ann; Govaere, Olivier; Cockell, Simon; Hyötyläinen, Tuulia; Mingrone, Geltrude; Bugianesi, Elisabetta; Anstee, Quentin M.; Orešič, Matej; Gastaldelli, Amalia
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )