Matej Oresic profile picture
Matej
Oresic
Senior Research Fellow, Turku Bioscience Centre
InFLAMES Flagship
Ph.D.

Contact

+358 29 450 3798
+358 46 923 3395
Tykistökatu 6
20520
Turku

Links

http://www.symmys.fi/matej.html
ORCID

Areas of expertise

Systems biology
bioinformatics
metabolomics
lipidomics
biophysics
systems medicine
computational biology

Biography

Professor Matej Orešič holds a PhD in biophysics from Cornell University. He is Professor of Medical Sciences with Specialization in Systems Medicine at School of Medical Sciences (Örebro University, Sweden), Group Leader in Systems Medicine at the Turku Bioscience Centre (University of Turku, Finland), and Guest Professor at the Oil Crops Research Institute Chinese Academy of Agricultural Sciences (Wuhan, PR China). His main research areas are metabolomics applications in biomedical research and integrative bioinformatics. He is particularly interested in the identification of disease vulnerabilities associated with different metabolic phenotypes and the underlying mechanisms linking these vulnerabilities with the development of specific disorders or their co-morbidities, with specific focus on obesity and diabetes and their co-morbidities. Dr. Orešič has also initiated the popular MZmine open source project, leading to popular software for metabolomics data processing. Previosuly, Dr. Orešič was principal investigator at Steno Diabetes Center (Gentofte, Denmark), research professor at VTT Technical Research Centre of Finland (Espoo, Finland), head of computational biology and modeling at Beyond Genomics, Inc. (Waltham/MA) and bioinformatician at LION Bioscience Research in Cambridge/MA. In 2016, Dr. Oresic received the Lifetime Honorary Fellow award from the Metabolomics Society.

Research

Our main research area is systems medicine, particularly metabolomics applications in biomedical research and related integrative bioinformatics. Specifically, we am particularly interested in the identification of disease vulnerabilities associated with different metabolic phenotypes and the underlying mechanisms linking these vulnerabilities with the development of specific disorders or their co-morbidities. Such in depth understanding of the metabolic phenotypes in health and disease is crucial if one is to implement personalized medicine. Dr. Orešič initiated the popular MZmine open source project, leading to popular software for metabolomics data processing. Main ongoing projects: Strategic Research Agreement, Juvenile Diabetes Research Foundation (9/2016-9/2018): Metabolomic and Proteomic markers staging progression to type 1 diabetes in autoantibody positive children – PI Strategic Research Agreement, Juvenile Diabetes Research Foundation (9/2016-9/2018): Mother-infant interactions in relation to potential biomarkers of beta-cell autoimmunity and type 1 diabetes – PI Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) - PI Strategic Research Agreement, Juvenile Diabetes Research Foundation (Integrative multi-omic study of early progression to type 1 diabetes; 2014-2017) - PI pHealth Programme, multi-PI collaborative project, Academy of Finland (Personalised medicine to predict and prevent Type 1 Diabetes; 9/2015-8/2019) – Co-PI EU H2020 EPoS (Elucidating Pathways of Steatohepatitis) - Workpackage leader EU FP7 METSY (Integrated neuroimaging and metabolic platform for characterisation of early psychosis and prediction of patient outcomes) - Coordinator

Publications

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Integrative analysis of multimodal mass spectrometry data in MZmine 3 (2023)

Nature Biotechnology
Schmid R, Heuckeroth S, Korf A, Smirnov A, Myers O, Dyrlund TS, Bushuiev R, Murray KJ, Hoffmann N, Lu MS, Sarvepalli A, Zhang Z, Fleischauer M, Durkop K, Wesner M, Hoogstra SJ, Rudt E, Mokshyna O, Brungs C, Ponomarov K, Mutabdzija L, Damiani T, Pudney CJ, Earll M, Helmer PO, Fallon TR, Schulze T, Rivas-Ubach A, Bilbao A, Richter H, Nothias LF, Wang MX, Oresic M, Weng JK, Bocker S, Jeibmann A, Hayen H, Karst U, Dorrestein PC, Petras D, Du XX, Pluskal T
(Kirjoitus tai data-artikkeli tieteellisessä aikakauslehdessä (B1))

Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function (2023)

Cardiovascular Research
Laudette Marion, Lindbom Malin, Arif Muhammad, Cinato Mathieu, Ruiz Mario, Doran Stephen, Miljanovic Azra, Rutberg Mikael, Andersson Linda, Klevstig Martina, Henricsson Marcus, Bergh Per-Olof, Bollano Entela, Aung Nay, Smith J.Gustav, Pilon Marc, Hyötyläinen Tuulia, Orešič Matej, Perkins Rosie, Mardinoglu Adil, Levin Malin C, Borén Jan
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Dynamics of the Lipidome in a Colon Simulator (2023)

Metabolites
Kråkström Matilda, Dickens Alex M, Amaral Alves Marina, Forssten Sofia D, Ouwehand Arthur C, Hyötyläinen Tuulia, Orešič Matej, Lamichhane Santosh
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Traumatic brain injury: progress and challenges in prevention, clinical care, and research (2022)

Lancet Neurology
Maas AIR, Menon DK, Manley GT, Abrams M, Akerlund C, Andelic N, Aries M, Bashford T, Bell MJ, Bodien YG, Brett BL, Buki A, Chesnut RM, Citerio G, Clark D, Clasby B, Cooper DJ, Czeiter E, Czosnyka M, Dams-O'Connor K, De Keyser V, Diaz-Arrastia R, Ercole A, van Essen TA, Falvey E, Ferguson AR, Figaji A, Fitzgerald M, Foreman B, Gantner D, Gao GY, Giacino J, Gravesteijn B, Guiza F, Gupta D, Gurnell M, Haagsma JA, Hammond FM, Hawryluk G, Hutchinson P, van der Jagt M, Jain S, Jain S, Jiang JY, Kent H, Kolias A, Kompanje EJO, Lecky F, Lingsma HF, Maegele M, Majdan M, Markowitz A, McCrea M, Meyfroidt G, Mikoli A, Mondello S, Mukherjee P, Nelson D, Nelson LD, Newcombe V, Okonkwo D, Oresic M, Peul W, Pisica D, Polinder S, Ponsford J, Puybasset L, Raj R, Robba C, Roe C, Rosand J, Schueler P, Sharp DJ, Smielewski P, Stein MB, von Steinbuchel N, Stewart W, Steyerberg EW, Stocchetti N, Temkin N, Tenovuo O, Theadom A, Thomas I, Espin AT, Turgeon AF, Unterberg A, Van Praag D, van Veen E, Verheyden J, Vande Vyvere T, Wang KKW, Wiegers EJA, Williams WH, Wilson L, Wisniewski SR, Younsi A, Yue JK, Yuh EL, Zeiler FA, Zeldovich M, Zemek R
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids (2022)

Clinical Nutrition
Gürdeniz Gözde, Uusitupa Matti, Hermansen Kjeld, Savolainen Markku J, Schwab Ursula, Kolehmainen Marjukka, Brader Lea, Cloetens Lieselotte, Herzig Karl-Heinz, Hukkanen Janne, Rosqvist Fredrik, Ulven Stine Marie, Gunnarsdóttir Ingibjörg, Thorsdottir Inga, Oresic Matej, Poutanen Kaisa S, Risérus U, Åkesson Björn, Dragsted Lars Ove
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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