Arno
Hänninen
Adjunct Professor, Faculty of Medicine
Clinical Lecturer, Institute of Biomedicine
MD, PhD, Adj. prof.
Areas of expertise
clinical and experimental immunology
pathogenesis of type 1 diabetes
gut microbiota
Biography
Present affiliation: Clinical teacher and Principal investigator (adj. professor), Institute of Biomedicine, University of Turku. Senior physician, Turku University Hospital Laboratory Division
Past affiliations: Academy of Finland Research Fellow; Prinicpal investigator in Center of Excellence in Cell Traffic (Academy of Finland affiliated), Postdoctoral researcher, WEHI (Walter and Eliza Hall Institute); Melbourne, Australia, PhD student and postdoc in Medical microbiology and Immunology (MediCity).
Past affiliations: Academy of Finland Research Fellow; Prinicpal investigator in Center of Excellence in Cell Traffic (Academy of Finland affiliated), Postdoctoral researcher, WEHI (Walter and Eliza Hall Institute); Melbourne, Australia, PhD student and postdoc in Medical microbiology and Immunology (MediCity).
Teaching
Clinical and basic immunology, clinical microbiology.
As a clinical teacher, I have responsibilities in organizing, implementing and developing the education of medical doctors, dentists and master students in biomedicine in the fields of microbiology and immunology.
Board member in Medial Faculty's education committee
As a clinical teacher, I have responsibilities in organizing, implementing and developing the education of medical doctors, dentists and master students in biomedicine in the fields of microbiology and immunology.
Board member in Medial Faculty's education committee
Research
My research is focused on gut microbiota and gut immune system. In particular, our interest is to understand how perturbations in gut microbiota link to autoimmunity and to the development of type 1 (T1D) diabetes. I have a long tradition in studying aspects of lymphocyte trafficking, gut-related homing mechanisms, peripheral immune tolerance and T-cell activation mechanisms. In addition, my more recent interest is to promote and contribute to clinical studies related to my diagnostic work.
We currently investigate the role of locally induced chemokines in the initiation of lymphocyte accumulation into islets in NOD mice. As a parallel facet, we explore how gut dysbiosis disrupts peripheral tolerance mechanisms in pancreatic lymph node to find ways to interfere with this.
In a prospective study in infants (www.samitutkimus.fi), we use novel tools to study individual differences in enzymatic activities of gut microbes and their relation to the maturation of healthy microbiota.
We currently investigate the role of locally induced chemokines in the initiation of lymphocyte accumulation into islets in NOD mice. As a parallel facet, we explore how gut dysbiosis disrupts peripheral tolerance mechanisms in pancreatic lymph node to find ways to interfere with this.
In a prospective study in infants (www.samitutkimus.fi), we use novel tools to study individual differences in enzymatic activities of gut microbes and their relation to the maturation of healthy microbiota.
Publications
Novel Hemizygous IL2RG p.(Pro58Ser) Mutation Impairs IL-2 Receptor Complex Expression on Lymphocytes Causing X-Linked Combined Immunodeficiency (2020)
Journal of Clinical Immunology
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
A carbohydrate-active enzyme (CAZy) profile links successful metabolic specialization of Prevotella to its abundance in gut microbiota (2020)
Scientific Reports
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Plasmacytoid dendritic cells regulate host immune response to Citrobacter rodentium induced colitis in colon-draining lymph nodes (2020)
European Journal of Immunology
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Granulocyte colony-stimulating factor- and chemotherapy-induced large-vessel vasculitis: six patient cases and a systematic literature review (2020)
Rheumatology Advances in Practice
(A2 Katsausartikkeli tieteellisessä aikauslehdessä)
Data-Independent Acquisition Mass Spectrometry in Metaproteomics of Gut Microbiota—Implementation and Computational Analysis (2020)
Journal of Proteome Research
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
CHEMOTHERAPY AND G-CSF INDUCED LARGE VESSEL VASCULITIS AND CAROTIDYNIA - SIX PATIENT CASES AND A SYSTEMATIC LITERATURE REVIEW (2019)
Annals of the Rheumatic Diseases
(O2 Muu)
Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice (2018)
Gut
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Activation of plasmacytoid dendritic cells by apoptotic particles - mechanism for the loss of immunological tolerance in Sjögren's syndrome (2018)
Clinical and Experimental Immunology
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Immunomonitoring of MSC-Treated GvHD Patients Reveals Only Moderate Potential for Response Prediction but Indicates Treatment Safety (2018)
Molecular therapy. Methods & clinical development
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)
Faecalibacterium prausnitzii Treatment Improves Hepatic Health and Reduces Adipose Tissue Inflammation in High-fat Fed Mice (2017)
ISME Journal
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)