Johanna Schleutker profile picture
Johanna
Schleutker
Professor, Institute of Biomedicine
PhD, Professor of Medical Genetics

Contact

+358 29 450 2726
+358 50 443 7237
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Cancer genetics
hereditary cancer
genomics
human genetics

Biography

Johanna Schleutker got her PhD in 1995 in University of Turku, Faculty of Medicine.The topic of her doctoral thesis was "Linkage disequilibrium is Salla disease; positioning of the sialic acid transport defect". She then moved to University of Tampere, and did her post doc in 1996-1998 in the Cancer Genetics research group of Professor Olli Kallioniemi. Her career continued in the US where she spent the years of 1999-2000 working as a research associate at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. During the NIH years, she studied genetics of familial prostate cancer in the group of Dr. Jeffrey M.Trent. After her return to Finland, Schleutker started her own research group in 2001 at the Insitute of Medical Technology, University of Tampere, and has ever since focused her studies on genetics and genetic susceptibility of prostate and breast cancer. Schleutker got a professorship in University of Tampere in 2008. In 2011 she started as a professor of medical genetics in University of Turku.

Teaching

Genetics, cancer genetics, hereditary cancer, genomics, molecular biology.

Research

The Schleutker group "Genetic Predisposition to Cancer" is studying both breast and prostate cancer genetics, the main emphasis being on prostate cancer. Of all cancers, prostate cancer (PrCa) has been reported as one of the most heritable diseases: genetic factors have been estimated to account for 57% of the risk. The goal is to identify and characterize predisposing genes and variants, especially those affecting aggressive outcome, including treatment responses to therapies. Further, the aim is to develop tools for prognostic purposes, i.e. prognostic biomarkers. The group has identified many significant genomic risk regions, candidate genes and variants, which have been then further profiled and characterized by functional studies. The group has produced (by 2021) 12 PhD degrees and published over 190 original, peer-reviewed articles in international journals.

Publications

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Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score (2022)

Prostate Cancer and Prostatic Diseases
Huynh-Le MP, Karunamuni R, Fan CC, Asona L, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir KR, Lophatananon A, Schleutker J, Pashayan N, Batra J, Gronberg H, Neal DE, Nordestgaard BG, Tangen CM, MacInnis RJ, Wolk A, Albanes D, Haiman CA, Travis RC, Blot WJ, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sorensen KD, Cybulski C, Grindedal EM, Menegaux F, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Lu YJ, Watya S, Vega A, Kogevinas M, Wiklund F, Penney KL, Huff CD, Teixeira MR, Multigner L, Leach RJ, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Ost P, Razack A, Newcomb LF, Fowke JH, Gamulin M, Abraham A, Claessens F, Castelao JE, Townsend PA, Crawford DC, Petrovics G, van Schaik RHN, Parent ME, Hu JJ, Zheng W, Mills IG, Andreassen OA, Dale AM, Seibert TM
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Multisite Evaluation and Validation of a Sensitive Diagnostic and Screening System for Spinal Muscular Atrophy that Reports SMN1 and SMN2 Copy Number, along with Disease Modifier and Gene Duplication Variants (2021)

Journal of Molecular Diagnostics
Milligan John N, Larson Jessica L, Filipovic-Sadic Stella, Laosinchai-Wolf Walairat, Huang Ya-Wen, Ko Tsang-Ming, Abbott Kristin M, Lemmink Henny H, Toivonen Minna, Schleutker Johanna, Gentile Caren, Van Deerlin Vivianna M, Zhu Huiping, Latham Gary J
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries (2021)

Nature Communications
Gharahkhani Puya, Jorgenson Eric, Hysi Pirro, Khawaja Anthony P., Pendergrass Sarah, Han Xikun, Ong Jue Sheng, Hewitt Alex W., Segrè Ayellet V., Rouhana John M., Hamel Andrew R., Igo Jr Robert P., Choquet Helene, Qassim Ayub, Josyula Navya S., Bailey Jessica N. Cooke, Bonnemaijer Pieter W. M., Iglesias Adriana, Siggs Owen M., Young Terri L., Vitart Veronique, Thiadens Alberta A. H. J., Karjalainen Juha, Uebe Steffen, Melles Ronald B., Nair K. Saidas, Luben Robert, Simcoe Mark, Amersinghe Nishani, Cree Angela J., Hohn Rene, Poplawski Alicia, Chen Li Jia, Rong Shi-Song, Aung Tin, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, UK Biobank Eye and Vision Consortium, GIGA study group, 23 and Me Research Team, Tamiya Gen, Shiga Yukihiro, Yamamoto Masayuki, Nakazawa Toru, Currant Hannah, Birney Ewan, Wang Xin, Auton Adam, Lupton Michelle K., Martin Nicholas G., Ashaye Adeyinka, Olawoye Olusola, Williams Susan E., Akafo Stephen, Ramsay Michele, Hashimoto Kazuki, Kamatani Yoichiro, Akiyama Masato, Momozawa Yukihide, Foster Paul J., Khaw Peng T., Morgan James E., Strouthidis Nicholas G., Kraft Peter, Kang Jae H., Pang Chi Pui, Pasutto Francesca, Mitchell Paul, Lotery Andrew J., Palotie Aarno, van Duijn Cornelia, Haines Jonathan L., Hammond Chris, Pasquale Louis R., Klaver Caroline C. W., Hauser Michael, Khor Chiea Chuen, Mackey David A., Kubo Michiaki, Cheng Ching-Yu, Craig Jamie E., MacGregor Stuart, Wiggs Janey L.; FinnGen Study
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness (2021)

Scientific Reports
Lin Hui-Yi, Huang Po-Yu, Cheng Chia-Ho, Tung Heng-Yuan, Fang Zhide, Berglund Anders E., Chen Ann, French-Kwawu Jennifer, Harris Darian, Pow-Sang Julio, Yamoah Kosj, Cleveland John L., Awasthi Shivanshu, Rounbehler Robert J., Gerke Travis, Dhillon Jasreman, Eeles Rosalind, Kote-Jarai Zsofia, Muir Kenneth, Schleutker Johanna, Pashayan Nora, Neal David E., Nielsen Sune F., Nordestgaard Børge G., Gronberg Henrik, Wiklund Fredrik, Giles Graham G., Haiman Christopher A., Travis Ruth C., Stanford Janet L., Kibel Adam S., Cybulski Cezary, Khaw Kay-Tee, Maier Christiane, Thibodeau Stephen N., Teixeira Manuel R., Cannon-Albright Lisa, Brenner Hermann, Kaneva Radka, Pandha Hardev, Srinivasan Srilakshmi, Clements Judith, Batra Jyotsna, Park Jong Y.; UKGPCS collaborators; APCB(Australian Prostate Cancer BioResource); The PRACTICAL consortium
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer (2021)

Prostate Cancer and Prostatic Diseases
Karunamuni Roshan A., Huynh-Le Minh-Phuong, Fan Chun C., Thompson Wesley, Eeles Rosalind A., Kote-Jarai Zsofia, Muir Kenneth, Lophatananon Artitaya, Schleutker Johanna, Pashayan Nora, Batra Jyotsna, Grönberg Henrik, Walsh Eleanor I., Turner Emma L., Lane Athene, Martin Richard M., Neal David E., Donovan Jenny L., Hamdy Freddie C., Nordestgaard Børge G., Tangen Catherine M., MacInnis Robert J., Wolk Alicja, Albanes Demetrius, Haiman Christopher A., Travis Ruth C., Stanford Janet L., Mucci Lorelei A., West Catharine M. L., Nielsen Sune F., Kibel Adam S., Wiklund Fredrik, Cussenot Olivier, Berndt Sonja I., Koutros Stella, Sørensen Karina Dalsgaard, Cybulski Cezary, Grindedal Eli Marie, Park Jong Y., Ingles Sue A., Maier Christiane, Hamilton Robert J., Rosenstein Barry S., Vega Ana, Kogevinas Manolis, Penney Kathryn L., Teixeira Manuel R., Brenner Hermann, John Esther M., Kaneva Radka, Logothetis Christopher J., Neuhausen Susan L., Razack Azad, Newcomb Lisa F., Gamulin Marija, Usmani Nawaid, Claessens Frank, Gago-Dominguez Manuela, Townsend Paul A., Roobol Monique J., Zheng Wei, Mills Ian G., Andreassen Ole A., Dale Anders M., Seibert Tyler M.; collaborators UKGPCS; APCB BioResource (Australian Prostate Cancer BioResource); The IMPACT Study Steering Committee and Collaborators; Canary PASS Investigators; The Profile Study Steering Committee; The PRACTICAL Consortium
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

BioCPR–A Tool for Correlation Plots (2021)

Data
Fey Vidal, Jambulingam Dhanaprakash, Sara Henri, Heron Samuel, Sipeky Csilla, Schleutker Johanna
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice (2021)

Scientific Reports
Messerschmidt Clemens, Foddis Marco, Blumenau Sonja, Müller Susanne, Bentele Kajetan, Holtgrewe Manuel, Kun-Rodrigues Celia, Alonso Isabel, Macario Maria do Carmo, Morgadinho Ana Sofia, Velon Ana Graça, Santo Gustavo, Santana Isabel, Mönkäre Saana, Kuuluvainen Liina, Schleutker Johanna, Pöyhönen Minna, Myllykangas Liisa, Senatore Assunta, Berchtold Daniel, Winek Katarzyna, Meisel Andreas, Pavlovic Aleksandra, Kostic Vladimir, Dobricic Valerija, Lohmann Ebba, Hanagasi Hasmet, Guven Gamze, Bilgic Basar, Bras Jose, Guerreiro Rita, Beule Dieter, Dirnagl Ulrich, Sassi Celeste
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))