Jukka Westermarck profile picture
Jukka
Westermarck
Professor, Institute of Biomedicine
Research Director, Turku Bioscience Centre
MD, PhD
Role and regulation of phosphatases, particularly tumor suppressor protein phosphatase 2A (PP2A) in human cancers

Contact

+358 29 450 2880
+358 40 742 3007
Tykistökatu 6
20520
Turku

Biography

Jukka Westermarck is a Professor of Cancer Biology, and Research Director, in the Turku Bioscience Centre at University of Turku. 

Westermarck earned his medical degree from University of Turku in 1996. Two years later he obtained his PhD degree in Department of Medical Biochemistry and Department of Dermatology at the same University. He was working as a postdoctoral fellow in the laboratory of Dirk Bohmann during 1999-2001 in the European Molecular Biology Laboratory in Heidelberg, Germany. After being appointed as Academy Fellow by the Academy of Finland, he established his own research group at Turku Centre for Biotechnology in 2002. In 2006-2009 he was appointed as a group leader in the Institute of Medical Technology at University of Tampere, and after that he returned back to Turku due to his appointment as a tenure Research Director of Turku Centre for Biotechnology, and as a Professor of Cancer Biology at the Faculty of Medicine. In 2012, he worked as a visiting Professor at Dana-Farber Cancer Institute, Boston.

Professor Westermarck received young researcher prize from Finnish Medical Association Duodecim 2007, and Anders Jahre young investigator prize 2009 from University of Oslo, Norway. In 2017, he became an elected member of the Finnish Academy of Science and Letters.

Research

Prof. Westermarck´s research focuses on role and regulation of phosphatases, particularly tumor suppressor protein phosphatase 2A (PP2A) in human cancers. Based on this work his group has identified several novel signaling principles how PP2A regulates cancer progression, as well as potential novel cancer therapy targets and diagnostic biomarkers.

Publications

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Druggable cancer phosphatases (2021)

Science Translational Medicine
Vainonen Julia P, Momeny Majid, Westermarck Jukka
(A2 Katsausartikkeli tieteellisessä aikauslehdessä)

Cancer stem cell phosphatases (2021)

Biochemical Journal
Momeny Majid, Arsiola Tiina, Westermarck Jukka
(A2 Katsausartikkeli tieteellisessä aikauslehdessä)

CIP2A interacts with TopBP1 and drives basal-like breast cancer tumorigenesis (2021)

Cancer Research
Laine Anni, Nagelli Srikar G., Farrington Caroline, Butt Umar, Cvrljevic Anna N., Vainonen Julia P., Feringa Femke M., Grönroos Tove J., Gautam Prson, Khan Sofia, Sihto Harri, Qiao Xi, Pavic Karolina, Connolly Denise C., Kronqvist Pauliina, Elo Laura L., Maurer Jochen, Wennerberg Krister, Medema Rene H., Joensuu Heikki, Peuhu Emilia, de Visser Karin, Narla Goutham, Westermarck Jukka
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer (2021)

Cell
Vervoort Stephin J, Welsh Sarah A, Devlin Jennifer R, Barbieri Elisa, Knight Deborah A, Offley Sarah, Bjelosevic Stefan, Costacurta Matteo, Todorovski Izabela, Kearney Conor J, Sandow Jarrod J, Fan Zheng, Blyth Benjamin, McLeod Victoria, Vissers Joseph HA, Pavic Karolina, Martin Ben P, Gregory Gareth, Demosthenous Elena, Zethoven Magnus, Kong Isabella Y, Hawkins Edwin D, Hogg Simon J, Kelly Madison J, Newbold Andrea, Simpson Kaylene J, Kauko Otto, Harvey Kieran F, Ohlmeyer Michael, Westermarck Jukka, Gray Nathanael, Gardini Alessandro, Johnstone Ricky W
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)