Leena Kainulainen profile picture
Leena
Kainulainen
Docent, Paediatrics and Adolescent Medicine

Contact

Areas of expertise

paediatrics
immunodeficiency
paediatric infectious diseases
respiratory infections
rhinovirus

Biography

Docent Leena Kainulainen graduated from medical school in 1995(University of Turku) and defended her PhD theses on CVID in 2000. She received specialist licence in paediatrics in 2005 and in pediatric infectious diseases 2013 and was appointed as a docent in paediatrics in 2013 (University of Turku). She is currently working as Head of the Division of Pediatric Care in Turku University Hospital and as an immunology consultant at Department of Pediatrics and Medicine at Turku University Hospital. She participates in neonatal screening for severe immunodeficiencies.


Teaching

Docent Kainulainen has been working as a clinical lecturer in pediatrics 2004 and 2006. Currently she teaches regularly medical students and paediatric residents as a part of her clinical duties.


Research

Docent Kainulainen´s research is  focused on primary immunodeficiency. Her current research interests comprise rhinovirus infections in primary hypogammaglobulinemia patients. Clinical trial on the treatment of rhinovirus infection with pegylated interferon alfa in CVID patients is ongoing. Research project on innate immunity in autoimmune patients is ongoing. In addition, she participates in research project aiming at  evaluating immunological status in pediatric patients with neonatal cardiac surgery.


Publications

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Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome (2022)

Journal of Allergy and Clinical Immunology
Leiding Jennifer W, Vogel Tiphanie P, Santarlas Valentine GJ, Mhaskar Rahul, Smith Madison R, Carisey Alexandre, Vargas-Hernández Alexander, Silva-Carmona Manuel, Heeg Maximilian, Rensing-Ehl Anne, Neven Bénédicte, Hadjadj Jérôme, Hambleton Sophie, Ronan Leahy Timothy, Meesilpavikai Kornvalee, Cunningham-Rundles Charlotte, Dutmer Cullen M, Sharapova Svetlana O, Taskinen Mervi, Chua Ignatius, Hague Rosie, Klemann Christian, Kostyuchenko Larysa, Morio Tomohiro, Thatayatikom Akaluck, Ozen Ahmet, Scherbina Anna, Bauer Cindy S, Flanagan Sarah E, Gambineri Eleonora, Giovannini-Chami Lisa, Heimall Jennifer, Sullivan Kathleen E, Allenspach Eric, Romberg Neil, Deane Sean G, Prince Benjamin T, Rose Melissa J, Bohnsack John, Mousallem Talal, Jesudas Rohit, Santos Vilela Maria Marluce Dos, O'Sullivan Michael, Pachlopnik Schmid Jana, Průhová Štěpánka, Klocperk Adam, Rees Matthew, Su Helen, Bahna Sami, Baris Safa, Bartnikas Lisa M, Chang Berger Amy, Briggs Tracy A, Brothers Shannon, Bundy Vanessa, Chan Alice Y, Chandrakasan Shanmuganathan, Christiansen Mette, Cole Theresa, Cook Matthew C, Desai Mukesh M, Fischer Ute, Fulcher David A, Gallo Silvanna, Gauthier Amelie, Gennery Andrew R, Gonçalo Marques José, Gottrand Frédéric, Grimbacher Bodo, Grunebaum Eyal, Haapaniemi Emma, Hämäläinen Sari, Heiskanen Kaarina, Heiskanen-Kosma Tarja, Hoffman Hal M, Gonzalez-Granado Luis Ignacio, Guerrerio Anthony L, Kainulainen Leena, Kumar Ashish, Lawrence Monica G, Levin Carina, Martelius Timi, Neth Olaf, Olbrich Peter, Palma Alejandro, Patel Niraj C, Pozos Tamara, Preece Kahn, Lugo Reyes Saúl Oswaldo, Russell Mark A, Schejter Yael, Seroogy Christine, Sinclair Jan, Skevofilax Effie, Suan Daniel, Suegeorgz Daniel, Szabolcs Paul, Velasco Helena, Warnatz Klaus, Walkovich Kelly, Worth Austen; STAT3 GOF Working Group members, Seppänen Mikko RJ, Torgerson Troy R, Sogkas Georgios, Ehl Stephan, Tangye Stuart G, Cooper Megan A, Milner Joshua D, Forbes Satter Lisa R
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation (2022)

Immunity
Masle-Farquhar E, Jackson KJL, Peters TJ, Al-Eryani G, Singh M, Payne KJ, Rao G, Avery DT, Apps G, Kingham J, Jara CJ, Skvortsova K, Swarbrick A, Ma CS, Suan D, Uzel G, Chua I, Leiding JW, Heiskanen K, Preece K, Kainulainen L, O'Sullivan M, Cooper MA, Seppänen MRJ, Mustjoki S, Brothers S, Vogel TP, Brink R, Tangye SG, Reed JH, Goodnow CC
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Multibatch Cytometry Data Integration for Optimal Immunophenotyping (2021)

Journal of Immunology
Ogishi Masato, Yang Rui, Gruber Conor, Zhang Peng, Pelham Simon J, Spaan András N, Rosain Jérémie, Chbihi Marwa, Han Ji Eun, Rao V Koneti, Kainulainen Leena, Bustamante Jacinta, Boisson Bertrand, Bogunovic Dusan, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child (2021)

Nature Medicine
Ogishi Masato, Yang Rui, Aytekin Caner, Langlais David, Bourgey Mathieu, Khan Taushif, Al Ali Fatima, Rahman Mahbuba, Delmonte Ottavia M., Chrabieh Maya, Zhang Peng, Gruber Conor, Pelham Simon J., Spaan András N., Rosain Jérémie, Lei Wei-Te, Drutman Scott, Hellmann Matthew D., Callahan Margaret K., Adamow Matthew, Wong Phillip, Wolchok Jedd D., Rao Geetha, Ma Cindy S., Nakajima Yuka, Yaguchi Tomonori, Chamoto Kenji, Williams Samuel C., Emile Jean-Francois, Rozenberg Flore, Glickman Michael S., Rapaport Franck, Kerner Gaspard, Allington Garrett, Tezcan Ilhan, Cagdas Deniz, Hosnut Ferda O., Dogu Figen, Ikinciogullari Aydan, Rao V. Koneti, Kainulainen Leena, Béziat Vivien, Bustamante Jacinta, Vilarinho Silvia, Lifton Richard P., Boisson Bertrand, Abel Laurent, Bogunovic Dusan, Marr Nico, Notarangelo Luigi D., Tangye Stuart G., Honjo Tasuku, Gros Philippe, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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