Päivi Koskinen profile picture
University Lecturer, Physiology and Genetics
Docent, Faculty of Science
PhD, Adj. prof.


+358 29 450 4218
+358 50 434 0905
Vesilinnantie 5

Areas of expertise

Cell signalling
Molecular Genetics
Protein kinases
Metastatic growth of cancer cells
Environmental biomonitoring
C. elegans nematodes


I finished my MSc studies in Biology in the University of Helsinki in 1987. I carried out PhD studies in the group of Prof. Kari Alitalo at the Hartman Institute and received the PhD degree in Molecular Genetics in the University of Helsinki in 1992. During years 1993-1996, I worked as a postdoctoral fellow in the group of Prof. Robert Eisenman at the Fred Hutchinson Cancer Research Center in Seattle, USA. In 1996, I returned back to Finland and joined the Turku Centre for Biotechnology as a group leader and a research fellow of the Academy of Finland. In 1997, I became Adjunct Professor of Molecular and Cell Biology in the Department of Biology, University of Turku, where I have been employed in teaching positions since 2006. Currently I work there as University Lecturer, sharing my time between research, teaching and administrative duties, as I also act as the departmental vice head for infrastructure.


As University Lecturer in Cell Physiology and Molecular Genetics, my courses have ranged from Cell and Animal Physiology and Environmental Toxicology to Molecular, Developmental and Evolutionary Genetics as well as Bioethics. I have been actively involved in developing the Scientia Aboensis teaching collaboration between the University of Turku and the Åbo Academy, including a course on Model organisms in Biological research. I am also responsible for the MSc thesis seminars, and continuously supervise undergraduate and graduate students as well as postdoctoral fellows.


The research in my group is currently divided into three major projects:

1. We analyse the physiological roles of PIM family kinases and their known or novel substrates, especially in the regulation of cancer cell motility and metabolism. There we use modern methods of molecular and cell biology, including CRISPR/Cas9-based genomic editing. Our studies are supported by our collaborations with chemists, who have provided us with PIM-selective inhibitors to be used as research tools.

2. We use the Caenorhabditis elegans nematodes as our model organisms to study evolutionarily conserved physiological functions of PIM-related kinases, such as regulation of chemosensation.  

3. We use the C. elegans nematodes also as bioindicators to monitor health hazards associated with environmental toxins, such as those derived from chemical or microbial contaminations.


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PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion (2021)

Journal of Biological Chemistry
Landor Sebastian K.J., Santio Niina M., Eccleshall William B., Paramonov Valeriy M., Gagliani Ellen K., Hall Daniel, Jin Shao-Bo, Dahlström Käthe M., Salminen Tiina A., Rivero-Müller Adolfo, Lendahl Urban, Kovall Rhett A., Koskinen Päivi J., Sahlgren Cecilia
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))