Sisko Tauriainen profile picture
Sisko
Tauriainen
University Lecturer, Institute of Biomedicine
PhD, Adjunct professor

Contact

+358 29 450 4554
+358 46 921 4201

Areas of expertise

Virology
Parechoviruses
Enteroviruses
Cell cultures

Biography

MSc, PhD in Biochemistry
Adjunct professor in Molecular biology/Molecular virology

Current position: University lecturer
Former positions: university teacher at University of Turku; senior researcher and earlier post-doctoral researcher at University of Tampere; post-doctoral researcher at Wayne State University, Detroit, Michigan; Doctoral student at University of Turku, department of Biochemistry

Major funding: Academy of Finland, Jane and Aatos Erkko Foundation

Student supervision: 4 PhD and over 20 undergraduate theses

Publications: over 40 refereed original research articles, 7 review articles or conference proceedings

Teaching

  1. Lectures: Enteric viruses, Virus life cycle, Picornaviruses
  2. Tutoring (Case Based Learning): Water and food borne viruses
  3. Lab courses: Microbial diagnostics

Research

Human parechoviruses (HPeVs) belong to the Picornavirdae family. They are small, non-enveloped and have a positive strand RNA genome of about 7300 bases. HPeV type 1 is a common virus infecting mainly children; practically everyone contacts it by the age of 3 years. HPeVs cause usually mild respiratory and gastrointestinal symptoms, but also severe central nervous systems infections, like meningitis, encephalitis and sepsis-like disease, have been detected in new-born babies. Mainly these severe symptoms are caused by HPeV3.
We have studied the HPeV epidemiology and disease connections and confirmed that HPeVs are common and the severe diseases do occur also in Finland. We were the first to identify HPeV4 as a serious disease causing type of these viruses in children with sepsis-like disease. Our studies focus on the disease causing abilities of these viruses and why the causative type is mostly HPeV3. The studies are done in human neuronal cell models, in vitro. The virus-cell interactions are studied and how the changes in virus genome affect virus infectivity, speed of virus replication as well as cellular metabolism and morphology.

Publications

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Neutralizing antibodies after the third COVID-19 vaccination in healthcare workers with or without breakthrough infection (2024)

Communications medicine
Reinholm Arttu, Maljanen Sari, Jalkanen Pinja, Altan Eda, Tauriainen Sisko, Belik Milja, Skön Marika, Haveri Anu, Österlund Pamela, Iakubovskaia Alina, Pasternack Arja, Naves Rauno A., Ritvos Olli, Miettinen Simo, Häkkinen Hanni K., Ivaska Lauri, Tähtinen Paula A., Lempainen Johanna, Kantele Anu, Kakkola Laura, Julkunen Ilkka, Kolehmainen Pekka
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Coronavirus spike protein-specific antibodies indicate frequent infections and reinfections in infancy and among BNT162b2-vaccinated healthcare workers (2023)

Scientific Reports
Kolehmainen Pekka, Huttunen Moona, Iakubovskaia Alina, Maljanen Sari, Tauriainen Sisko, Yatkin Emrah, Pasternack Arja, Naves Rauno, Toivonen Laura, Tähtinen Paula A, Ivaska Lauri, Lempainen Johanna, Peltola Ville, Waris Matti, Kakkola Laura, Ritvos Olli, Julkunen Ilkka
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

A Combination of N and S Antigens With IgA and IgG Measurement Strengthens the Accuracy of SARS-CoV-2 Serodiagnostics (2021)

Journal of Infectious Diseases
Jalkanen P, Pasternack A, Maljanen S, Melén K, Kolehmainen P, Huttunen M, Lundberg R, Tripathi L, Khan H, Ritvos MA, Naves R, Haveri A, Österlund P, Kuivanen S, Jääskeläinen AJ, Kurkela S, Lappalainen M, Rantasärkkä K, Vuorinen T, Hytönen J, Waris M, Tauriainen S, Ritvos O, Kakkola L, Julkunen I
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants (2021)

Nature Communications
Jalkanen Pinja, Kolehmainen Pekka, Häkkinen Hanni K., Huttunen Moona, Tähtinen Paula A., Lundberg Rickard, Maljanen Sari, Reinholm Arttu, Tauriainen Sisko, Pakkanen Sari H., Levonen Iris, Nousiainen Arttu, Miller Taru, Välimaa Hanna, Ivaska Lauri, Pasternack Arja, Naves Rauno, Ritvos Olli, Österlund Pamela, Kuivanen Suvi, Smura Teemu, Hepojoki Jussi, Vapalahti Olli, Lempainen Johanna, Kakkola Laura, Kantele Anu, Julkunen Ilkka
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))