PI and co-PI’s:Andre Sourander, Marjo Kurki, Yifeng Wei.
Research at the Research Centre for Child Psychiatry
Our research focuses on large birth cohort studies, population-based studies, intervention studies and cross cultural studies.
The projects aim at
- identifying early biological and psychosocial risk factors of mental health disturbances
- increasing general understanding of etiology, developmental trajectories and early predictors of childhood and adulthood psychiatric disorders, antisocial behavior and marginalization
- providing the basis for further studies of gene-environment interactions
- promoting implementation of research findings into clinical practice
- developing and studying effectiveness of early interventions for children at risk.
Finnish Psychiatric Birth Cohort Consortium PSYCOHORTS
The Finnish Psychiatric Birth Cohort Consortium (PSYCOHORTS) combines the major prospectively designed Finnish psychiatric birth cohorts. The integration of these cohorts will enable us to address issues related to the development, trajectories and life outcomes of psychiatric disorders.
Unique from a global perspective, Finland has several nationwide registers and a biobank of maternal sera. Linkages can be made between registers, biobank data and records from health check-ups. The PSYCOHORTS Consortium comprises of eight prospective birth cohorts in Finland: the Northern Finland Birth Cohorts 1966 and 1986, Finnish 1981 Birth Cohort Study, Finnish Prenatal Studies, 1987 and 1997 Birth Cohorts, SSRI pregnancy cohort and Southwest Finland Birth Cohort. The integration of these cohorts enables us to address issues related to the life course development of psychiatric disorders. Data spanning from 1960s to date allows us to study time trends between different cohorts and between different time points.
The consortium is funded the Academy of Finland Programme Health from Cohorts and Biobanks from 2017 to 2020.
PI: Andre Sourander, University of Turku
Juha Veijola, University of Oulu
Mika Gissler, National Institute for Health and Welfare
Lapset 1981 cohort study (FNBCS-1981)
The Finnish Birth Cohort is a nationwide representative sample of 10% of all children born in 1981 in Finland (N=6,014) followed until age 37. Data on maternal health during pregnancy and labor, neonatal events, developmental milestones and growth have been collected from medical records.
At age eight, 97% of children were assessed using questionnaires. The parents and the teacher completed questionnaires with items concerning family structure, parental education level, conduct problems, hyperactive problems, emotional symptoms, bullying, and victimization of bullying behavior. The children themselves completed the Children’s Depression Inventory with questions regarding depressive symptoms, and extra questions regarding bullying, and victimization of bullying behavior.
Data on psychiatric symptoms and sense of coherence in conscripts were collected and register-based data on treatment for psychiatric disorders, crimes, psychotropic medication use, abortions, teenage pregnancies and family history of psychiatric disorders are available.
The consortium is funded the Academy of Finland
PI and co-PI’s: Docent David Gyllenberg, Docent Venla Lehti, Prof. Andre Sourander.
The Finnish Prenatal Studies is a large case-control study examining prenatal and early development factors associated with major neuropsychiatric disorders. The subprojects include studies on schizophrenia, bipolar disorder, autism, ADHD, conduct disorder, anxiety, Tourette Syndrome, depression and obsessive compulsive disorder.
FIPS is the largest seroepidemiologic study of prenatal exposures in psychiatric disorders using archived prenatal sera, based on the Finnish Maternity Cohort (FMC). The samples were obtained from over 98% of all pregnancies in Finland in 1983-2016 (2 million pregnancies) during the first trimester.
The team has used register based information including obstetric complications, gestational age and birth weight, indicators for hypoxia, neonatal disorders, family psychopathology, and parental age.
The findings include showing that several maternal prenatal biomarkers including cotinine, vitamin D and inflammatory markers, other early developmental factors, and family history of psychiatric disorder are independently associated with neuropsychiatric disorders
Main funding: National Institutes of Health, National Institutes of Mental health, Autism Speaks Foundation, several other foundations and Turku University Hospital Tyksin erityisvastuualueen (Erva) tutkimustoimikunnan valtion tutkimusrahoitus.
PI and co-PI’s: prof. Andre Sourander, docent Heljä-Marja Surcel, docent Roshan Chudal, docent David Gyllenberg, MD, PhD Kim Kronström, prof. Alan Brown.
Fips study desing
Neuropsychiatric disorders with an onset in childhood such as Autism spectrum disorder (ASD), Tourette syndrome (TS), attention-deficit/hyperactivity disorder (ADHD) and conduct disorders (CD) have not been thoroughly studied for risk of suicidality.
In this project we study the prevalence and potential risk factors associated with completed suicides and severe suicide attempts among children and adolescents with neuropsychiatric disorders. The aim is to advance early identification of high-risk groups among NPDs for severe suicidal behavior.
The nationwide, population-based, nested case-control, follow-up study is based on Finnish registers including several thousands of cases per studied disorder together with 4 matched controls per case.
- Autism spectrum disorder: 4698 cases and 18792 controls
- Tourette syndrome: 2919 cases and 11 676 controls
- Attention-deficit/hyperactivity disorder (ADHD): 10 367 cases and 41 468 controls
- Conduct disorders: 12554 cases and 50216 controls.
Main funding: American Foundation of Suicide Prevention
PI and co-PI’s: Docent David Gyllenberg, docent Roshan Chudal, Professor Andre Sourander
The study investigates long-term risk factors in offspring for the maternal use of SSRIs during pregnancy, whether the fetus is particularly sensitive to the effects of SSRIs at a spesific stage of pregnancy and whether there are differences between the antidepressants in terms of fetal safety. The study is conducted in collaboration between the University of Turku, and Columbia University, New York.
Registers used: Medical Birth Register, Register of Congenital Malformations, Drug Reimbursement Register, Hospital Discharge Register, and Population Register.
Funding: National Institutes of Mental Health, USA.
PI & co-PI’s: Heli Malm, David Gyllenberg, Andre Sourander, Susanna Hinkka-Yli-Salomäki, Mika Gissler, Alan Brown (Columbia University)
The main objective is to study how the children's and adolescents' mental health, perceived need of help, psychiatric diagnoses and the use of psychiatric inpatient and outpatient services has developed by sex and geographic area in Finland during the last three decades.
•A multi-method approach with significant data triangulation
•Nationally inclusive register-based data in a longitudinal setting allowing for population-based estimates in large numbers
•Rare exposures and outcomes studied by using register-based data where no participation, research- or reporting bias can affect the results
•Separately collected cohort data with clinical measurements and self-reported data collected to get more specific information on health outcomes among children, adolescent and young adults.
Main funding: Academy of Finland
PI and co-PI’s: Mika Gissler, Tiina Ristikari, Andre Sourander, David Gyllenberg, Terhi Luntamo, Lotta Lempinen, Kaisa Mishina
We develop, evaluate and implement digitally delivered, preventive interventions aiming at increasing the psychosocial wellbeing of children, adolescent and families, as well as digitalized low-threshold targeted interventions to tackle mental health problems that start in childhood and early adolescence and have high public health significance.
Our aim is to develop and study the efficacy of interventions with high public health significance targeting critical transitional periods in child’s development.
The main aim of the project is to evaluate the effectiveness of the digitalized CBT-intervention “YHDESSÄ VAHVAKSI” in treatment of perinatal depressive symptoms in mothers screened from the general population. We will also assess the personal, familial and treatment-related factors that may affect the impact of the treatment.
Population: Pregnant women attending the maternity clinic at 15th to 16th gestational week and screened for symptoms of antenatal depression. Target population is 10,000 mothers and estimated 500 are included in the study.
PI and co-PI’s: Andre Sourander, Terja Ristkari, Tarja Korpilahti-Leino, Tarja Koffert, Miika Vuori
The objective of this study is to evaluate the effectiveness of a self-directed, digitally delivered universal parenting program among families with 3-year-old children. The effectiveness of the program will be assessed using a randomized, controlled, single-blinded clinical trial with a pragmatic, two-arm group with waiting list design.
Population: All parents with a 3-year old child recruited from child health clinics.
PI and co-PI’s: Andre Sourander, Kaisa Mishina, Terja Ristkari, Malin Kinnunen
Oppositional and conduct problems are developmental precursors to a wide range of negative outcomes that indicate a later risk of marginalization, including peer rejection, school failure, psychopathology, substance abuse, criminality and suicidality. Approximately half of the preschool children who are identified as aggressive and have externalizing behavior develop persistent problems. Untreated disruptive behavior disorders are some of the most costly early childhood psychiatric disorders.
Parental training is the most effective approach to the psychosocial treatment of disruptive behavior and one of the best‐validated therapeutic techniques. Parents who take part in training interventions typically learn to identify, define and observe problem behaviors in new ways and acquire strategies to prevent and respond to oppositional behavior.
Voimaperheet intervention is based on telephone coaching, evidence-based digitalized psychoeducation and parent training. The families have been identified as part of the risk group during their fourth-year visit to a child health clinic. The Finnish child health clinics provide regular check-ups that offer universal health care and are attended by 99.6% of the children.
The Randomized Controlled Trial (RCT) was conducted on an intervention offering remote or internet-assisted parental training and population-based screening. The follow-up and implementation studies are ongoing.
PI and co-PI’s: Andre Sourander, Terja Ristkari, Marjo Kurki, Susanna Hinkka-Yli-Salomäki
Anxiety is the most common psychiatric problem in childhood. It causes significant functional impairment at home, school and in social situations. Significant comorbid problems include subsequent anxiety, depression, substance abuse, and even suicide attempts, indicating a risk for adverse developmental pathways, decreased work readiness and finally marginalization, causing significant suffering, as well as economic burden on society.
However, children with anxiety often remain untreated, as the symptoms easily remain unidentified, even by their parents. Additionally, there is a significant lack of therapists, and in some areas, there are no therapists at all.
The aim of this study is to develop an internet-based cognitive-behavioral intervention with telephone coaching, “HUOLET HALLINTAAN”, and study it’s efficacy among school-aged children, whose anxiety symptoms are screened at routine school health care check-ups. Systematic symptom screening combined with an easily accessible treatment program creates an exceptional opportunity to reach those children, whose symptoms have not been recognized, or who have not had an opportunity to get treated.
PI and co-PI’s: Andre Sourander, Terja Ristkari, Tarja Korpilahti-Leino, Terhi Luntamo, Susanna Hinkka-Yli-Salomäki
There are many barriers for seeking help in mental health care services, including lack of knowledge about and negative attitudes towards mental disorders and treatment, and poor access to appropriate care. Educational interventions on Mental Health Literacy (MHL) – understanding how to obtain and maintain good health, understanding mental disorders and their treatment, decreasing stigma and enhancing help-seeking behavior – are needed to promote good mental health.
First year at the university is a challenging phase at a young adult’s life. According to many studies, especially medical students have a high risk of stress-related problems, mental health problems, depression and anxiety due to demands of the studies and their future profession, posing a threat to their wellbeing.
Transitions/ Kohti uutta is an intervention study to evaluate how digitally delivered mental health literacy intervention changes mental health knowledge, attitudes and help-seeking behavior among first year medical students.
Majority of existing research in child and adolescent psychiatry originates from the Western countries, and its’ findings have long been considered to be valid also for the rest of the world. This extrapolation without comparable data is unlikely to present the true picture.
The overall aim of the projects is to conduct cross-cultural, multisite research on well-being and mental health among children and adolescents.
Eurasian Child and Adolescent Mental Health Study (EACMHS) group, a network of researchers and clinicians, was established in 2016 to answer to the need for collaborative research addressing vital issues in child and adolescent psychiatry. The EACMHS network includes leading child and adolescent psychiatrists and psychology experts from the following countries: Bahrain, China, Finland, Greece, India, Indonesia, Iran, Israel, Japan, Lithuania, Nepal, Norway, Russia, Singapore, Switzerland, Thailand, Ukraine, and Vietnam.
Andre Sourander (University of Turku, Finland), Roshan Chudal (University of Turku, Finland) , Norbert Skokauskas (Norwegian University of Science and Technology; Norway) , Ahmed Malallah Al-Ansari (Arabian Gulf University, Bahrain), Anat Brunstein Klomek (Interdisciplinary Center (IDC) Herzliya, Israel ), Chanvit Pornnoppadol (Mahidol University, Thailand) , Gerasimos Kolaitis (National and Kapodistrian University of Athens, Greece) , Hans-Cristoph Steinhausen (University of Basel, University of Zurich, Switzerland, Region Psychiatry Copenhagen, Denmark) , Helena Slobodskaya (Institute of Physiology and Basic Medicine, Russia Novosibirsk State University, Russia) , Hitoshi Kaneko (Nagoya University, Japan), Jaya Regmee (Child and Adolescent Psychiatry Department, Kanti Children's Hospital/Child Workers in Nepal Concerned Centre (CWIN), Nepal), Liping Li (Shantou University and Medical School, China), Mai Huong Nguyen (Department of Psychiatry, National Hospital of Pediatrics, Vietnam), Meytal Grimland (Tel Aviv University, Israel), Olga Osokina (Donetsk National Medical University, Ukraine), Say How Ong (Institute of Mental Health, Singapore), Samir Kumar Praharaj (Department of Psychiatry, Kasturba Medical College, Manipal, Manipal University, India), Sigita Lesinskienė (Vilnius University, Lithuania) , Sturla Fossum (University of Tromsø, Norway), Tjhin Wiguna (University of Indonesia, Indonesia), Valentina A. Makasheva (Novosibirsk Regional Psycho-neurology Clinic for Children and Adolescents, Russia), Venla Lehti (University of Turku; Department of Psychiatry, Helsinki University Hospital and University of Helsinki, Finland), Elina Tiiri (University of Turku, Turku, Finland).
Follow-up study on psychiatric symptoms experienced by adolescents in Nepal following the 2015 earthquake – Dr. Sanju Silwal, Docent Roshan Chudal, Prof. Lars Lien, Prof. Andre Sourander, Dr. Ragnhild Dybdahl
Dr. Olga Osokina, Prof. Norbert Skokauskas
Japan, Nagoya, Prof. Hitoshi Kaneko
Indonesia, Jakarta, Dr. Fransiska Kaligis
Kenya, Nairobi, Prof. David Ndetei