Keyword: Alzheimer's disease

A Finnish population study shows that signs related to Alzheimer’s disease may already be found in the brain in middle age. In the future, blood-based biomarkers associated with Alzheimer's disease could allow earlier detection of the disease. This would allow preventive treatment to be targeted at the right individuals while the disease is still at the mild stage.

Researchers from the University of Turku and Åbo Akademi University in Finland and the University of Wisconsin in the United States demonstrated that individuals who had childhood epilepsy have an increased accumulation of brain amyloid later in life, potentially predisposing them to late-onset brain amyloid disorders, such as Alzheimer's disease.

Diabetes is a risk factor for cognitive decline. In a study of the University of Turku and Finnish Institute for Health and Welfare, the researchers observed that already a higher two-hour glucose level in the glucose tolerance test predicts worse performance in a test measuring episodic memory after ten years. Decline in episodic memory is one of the first symptoms of Alzheimer’s disease.

Researchers have discovered new changes in blood samples which are associated with Alzheimer’s disease. A new international study examined Finnish twins. The study was conducted on disease-discordant twin pairs: one sibling who suffered from Alzheimer’s disease and one who was cognitively healthy. The researchers utilised the latest genome-wide methods to find out whether the twins’ blood samples had any disease-related differences in chemical marks, so-called epigenetic marks, which are sensitive to changes in environmental and lifestyle factors.