Keyword: Turku Bioscience

Biomedical research often occurs in painfully slow pace. Here, as an alternative approach we aim to pilot rapid research and collaboration. This takes a form of an experimental biomedical workshop / mini-hackathon called “SpeedFish” utilizing rapid zebrafish models for cardiovascular biology and disease.

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska’s research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing SORLA from cancer cells sensitised anti-HER2 resistant breast cancer brain metastasis to targeted therapy.