Keyword: Turku PET Centre

Insulin is a key hormone in energy metabolism and blood sugar regulation. Normal insulin function in the body may be disturbed by e.g. overweight, leading to decreased insulin sensitivity and increased risk of developing type 2 diabetes and cardiovascular diseases. In a Finnish collaborative study of Turku PET Centre and UKK institute, the researchers noticed that standing is associated with better insulin sensitivity. Increasing the daily standing time may therefore help prevent chronic diseases.

Doctoral Candidate Tuulia Malén from the University of Turku Doctoral Programme in Clinical Research (DPCR) won SANORD 3MT 2021 competition together with two other finalists.

Brain regulation of feeding behaviour traits has remained incompletely understood. In their latest study, researchers at the Turku PET Centre, Finland, discovered a connection between the function of the opioid system and food craving triggered by appetitive external stimuli.

Researchers from the Turku PET Centre and Technical University of Munich have discovered a new mechanism controlling satiation. According to the recently published study, the hormone secretin induces satiation by activating brown adipose tissue.

The preliminary trial results of a novel radiopharmaceutical for PET imaging of inflammation developed at the University of Turku, Finland, have been published. The compound, which targets the vascular adhesion protein 1 (VAP-1) that regulates inflammatory cell traffic, is the first radiopharmaceutical that has been developed completely in Finland and has advanced to clinical trials. In the study that started with healthy volunteers, the radiopharmaceutical was found to be well tolerated and safe.

According to a Finnish study, the structure and function of the brain areas involved in emotions and their regulation are altered in both psychopathic criminal offenders and otherwise well-functioning individuals who have personality traits associated with psychopathy.

A Finnish research group has studied how seasons influence the function of the brain. Researchers at the Turku PET Centre showed that the length of daylight affects the opioid receptors, which in turn regulates the mood we experience.

Recently published research has indicated that folate receptor targeting therapy constrains inflammation in inflammatory demyelinating central nervous system lesions and may inhibit progression of the disease in animal model of multiple sclerosis (MS). This research has been conducted in co-operation with Turku PET Centre, Purdue University and Endocyte Inc (now part of Novartis Institutes for BioMedical Research, NIBR).

What happens in the brain when our conscious awareness of the surrounding world and of ourselves fades during general anesthesia and normal sleep? This fundamental question was studied with novel experimental designs and functional brain imaging by Finnish scientists. They succeeded in separating the specific changes related to consciousness from the more widespread overall effects, commonly misinterpreted as the neural correlates of consciousness. The effects of anesthesia and sleep on brain activity turned out to be surprisingly similar.

Researchers at the University of Turku have discovered what type of neural mechanisms are the basis for emotional responses to music. Altogether 102 research subjects listened to music that evokes emotions while their brain function was scanned with functional magnetic resonance imaging (fMRI). The study was carried out in the national PET Centre.