Diabetes is a risk factor for cognitive decline. In a study of the University of Turku and Finnish Institute for Health and Welfare, the researchers observed that already a higher two-hour glucose level in the glucose tolerance test predicts worse performance in a test measuring episodic memory after ten years. Decline in episodic memory is one of the first symptoms of Alzheimer’s disease.
Keyword: Turku PET Centre
Researchers Observed Association between Standing and Insulin Sensitivity – Standing More May Help Prevent Chronic Diseases
Insulin is a key hormone in energy metabolism and blood sugar regulation. Normal insulin function in the body may be disturbed by e.g. overweight, leading to decreased insulin sensitivity and increased risk of developing type 2 diabetes and cardiovascular diseases. In a Finnish collaborative study of Turku PET Centre and UKK institute, the researchers noticed that standing is associated with better insulin sensitivity. Increasing the daily standing time may therefore help prevent chronic diseases.
Brain regulation of feeding behaviour traits has remained incompletely understood. In their latest study, researchers at the Turku PET Centre, Finland, discovered a connection between the function of the opioid system and food craving triggered by appetitive external stimuli.
Researchers from the Turku PET Centre and Technical University of Munich have discovered a new mechanism controlling satiation. According to the recently published study, the hormone secretin induces satiation by activating brown adipose tissue.
Promising Results from First-in-Humans Study of a Novel PET Radiopharmaceutical - Study Continues with Rheumatoid Arthritis Patients
The preliminary trial results of a novel radiopharmaceutical for PET imaging of inflammation developed at the University of Turku, Finland, have been published. The compound, which targets the vascular adhesion protein 1 (VAP-1) that regulates inflammatory cell traffic, is the first radiopharmaceutical that has been developed completely in Finland and has advanced to clinical trials. In the study that started with healthy volunteers, the radiopharmaceutical was found to be well tolerated and safe.
According to a Finnish study, the structure and function of the brain areas involved in emotions and their regulation are altered in both psychopathic criminal offenders and otherwise well-functioning individuals who have personality traits associated with psychopathy.
A Finnish research group has studied how seasons influence the function of the brain. Researchers at the Turku PET Centre showed that the length of daylight affects the opioid receptors, which in turn regulates the mood we experience.
A Novel Folic Acid Linked Drug Has Shown to Attenuate Inflammation and Disease Activity in Animal Model of Multiple Sclerosis
Recently published research has indicated that folate receptor targeting therapy constrains inflammation in inflammatory demyelinating central nervous system lesions and may inhibit progression of the disease in animal model of multiple sclerosis (MS). This research has been conducted in co-operation with Turku PET Centre, Purdue University and Endocyte Inc (now part of Novartis Institutes for BioMedical Research, NIBR).
Imaging the Twilight Zone − General anesthesia and normal sleep affect brain in an amazingly similar way as consciousness fades
What happens in the brain when our conscious awareness of the surrounding world and of ourselves fades during general anesthesia and normal sleep? This fundamental question was studied with novel experimental designs and functional brain imaging by Finnish scientists. They succeeded in separating the specific changes related to consciousness from the more widespread overall effects, commonly misinterpreted as the neural correlates of consciousness. The effects of anesthesia and sleep on brain activity turned out to be surprisingly similar.
Researchers at the University of Turku have discovered what type of neural mechanisms are the basis for emotional responses to music. Altogether 102 research subjects listened to music that evokes emotions while their brain function was scanned with functional magnetic resonance imaging (fMRI). The study was carried out in the national PET Centre.