Jonne Laurila profiilikuva
Jonne
Laurila
yliopisto-opettaja, biolääketieteen laitos
PhD, Associate professor in pharmacology

Ota yhteyttä

+358 40 065 5159
Kiinamyllynkatu 10
20520
Turku

Tutkimus

My research focuses on the molecular pharmacology of human alpha2-adrenoceptors and octopamine receptors of the barnacle Balanus improvisus.

Octopamine receptors of insects represent counterparts of the adrenoceptors in vertebrate animals. The alpha2-adrenoceptor agonist medetomidine, known as a veterinary sedative agent, was discovered to inhibit the settling process of barnacles by inducing hyperactivity in the barnacle larvae. Our goal is to find compounds that activates only octopamine receptors of the Balanus improvisus but not the alpha2-adrenoceptors of vertebrates. These compounds could act as an antifouling agents. For this purpose we have developed novel cell-based screening and profiling assays to identify selective compounds for these receptors.

In addition, our interest is to study the ligand binding properties at human alpha2-adrenoceptors. For this purpose we have cell lines expressing the three subtypes of human alpha2-adrencoeptors.


Julkaisut

Järjestä:

A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin (2016)

Bioorganic and Medicinal Chemistry
Jelica Vucicevic, Tatjana Srdic-Rajic, Marco Pieroni, Jonne M. M. Laurila, Vladimir Perovic, Sabrina Tassini, Elisa Azzali, Gabriele Costantino, Sanja Glisic, Danica Agbaba, Mika Scheinin, Katarina Nikolic, Marco Radi, Nevena Veljkovic
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Synthesis and biological activities of 2- [(heteroaryl)methyl]imidazolines (2012)

Bioorganic and Medicinal Chemistry
Saczewski Jaroslaw, Hudson Alan, Scheinin Mika, Rybcynska Apolonia, Ma Daqing, Saczewski Franciszek, Laird Shayna, Laurila Jonne M, Boblewski Konrad, Lehmann Artur, Gu Jianteng, Watts Helena
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))