medicity

MediCity tutkimuslaboratorio

Medicity on Turun yliopiston lääketieteellisen tiedekunnan alla toimiva tutkimuslaboratorio.

Tietoa meistä

Medicityssä toimii kliinisen, biolääketieteen ja hammaslääketieteen laitoksen tutkimusryhmiä (yhteensä noin 100 tutkijaa ja avustavaa henkilökuntaa). Tutkimusaiheet kattavat laajasti biomedisiinisen tutkimuksen osa-alueita kuten immunopuolustus, kuvantaminen, syöpätutkimus sekä tulehdustaudit. Tutkimusryhmät kuuluvat pääsääntöisesti tiedekunnan tutkimusohjelmiin.

Medicityn johtajana toimii Akateemikko Sirpa Jalkanen

Uutiset ja tapahtumat

Medicityn tutkimushanke on saanut merkittävän rahoituksen Suomen Akatemian lippulaivaohjelmasta 

Tutkimushanke Innovation Ecosystem Based on the Immune System (InFLAMES) on saanut Suomen Akatemian lippulaivaohjelmasta 5,6 miljoonan euron rahoituksen vuosille 2020–2023. Lippulaiva tähtää uusien lääkekehityskohteiden tunnistamiseen ja varsinaiseen lääkekehitykseen yhdessä biotekniikka- ja lääkeyritysten kanssa. InFLAMES edistää myös diagnostiikkaa, jotta kullekin potilaalle voitaisiin räätälöidä sopivat täsmähoidot.

Professori Sirpa Jalkanen
Professori, akateemikko Sirpa Jalkanen

Hanketta johtaa Medicityn johtaja, Turun yliopiston professori, akateemikko Sirpa Jalkanen, joka on arvostettu ja palkittu immunologian tutkija ja lääkealan yritysyhteistyön asiantuntija. Hankkeen toteuttavat Turun yliopisto ja Åbo Akademi, jotka ovat useiden vuosien ajan tehneet yhteistyötä lääkekehityksen ja diagnostiikan tutkimusprofiilissa.

Lue lisää:

InFLAMES projektin nettisivut: https://inflames.utu.fi/

Turun yliopiston uutinen: 

https://www. utu.fi/fi/ajankohtaista/mediatiedote/immuunijarjestelman-ja-laakekehityksen-lippulaivalle-5-6-miljoonan-rahoitus 

 

MUITA UUTISIA

2020

Klaus Elenius on valittu Suomalaisen Tiedeakatemian jäseniksi. Jäseneksi kutsutaan ansioituneita tieteenharjoittajia, ja heitä valitsemassa ovat tieteen huiput, Tiedeakatemian jäsenet. Lista valituista. [4.9]

Sirpa Jalkanen osallistuu Eurooppa-foorumin keskusteluun: Turun terveysklusteri eurooppalaisen tutkimuksen veturina, lääkekehityksessä ja kuvantamisessa – Vahvuusalueet ja merkitys akuuttien terveysongelmien ratkaisemisessa. [Eurooppa-foorumi 27.8]

Journal of Cell Science First person interview – Karolina Losenkova (Jalkanen Group) [JoCSF 29.5]

Sakari Alhopuron säätiöltä liki 500 000 euroa Turun yliopiston lääketieteen ja luonnontieteen tutkijoille. Saajien joukossa Akira Takeda [UTU 28.5]

Kortikosteroidit vaarallisia virustautien hoidossa [UTU 28.5]

Syövän immunoterapian tutkimus- ja innovaatiotoiminnan kehittämiseen 10 miljoonan euron investointi [UTU 11.5]

Academy Research Fellow BTY rajoitusta Medicityn tutkijoille

  • De Figueiredo, Rogerio (Hollmen Group): "Targeting myeloid MIF/CD74 axis in metastatic melanoma – mechanisms, prognostication and therapeutic opportunities" - 438 874 €
  • Takeda, Akira (Jalkanen Group): "The Impact of Endothelial and Stromal Cell Heterogeneity on Cancer Cell Fitness" - 438 874 €

[27.4 Suomen Akatemia rahoituspäätökset]

Veli-Matti Kähärin ja Jyrki Heinon tutkimukselle Juséliuksen säätiön suuri apuraha [UTU 24.4]

Kari Kurpalle 100 000€ apuraha Instrumentariumin tiedesäätiöltä yli 500 000 euroa turkulaiselle lääketieteen tutkimukselle [UTU 23.3]

Apurahansaajien joukossa Medicitystä Johanna Lempainen, Marko Salmi, Sirpa Jalkanen, Jorma Toppari, Kari Kurppa ja Maija Hollmen Biolääketieteen laitoksen tutkijoille yli miljoona euroa Juséliuksen säätiöltä [UTU 20.3]

Väitös (lastentautioppi): FM Marjaana Mäkinen [UTU 21.2]

Turun yliopiston diabetestutkimukselle merkittävä rahoitus Yhdysvalloista [UTU 24.2]

D-vitamiinilla ei ole yhteyttä tyypin 1 diabetekseen sairastumiseen [Aamuset 17.2]

D-vitamiinilla ei ole yhteyttä tyypin 1 diabetekseen sairastumiseen [Lääkärilehti 17.2]

D-vitamiinilla ei ole yhteyttä tyypin 1 diabetekseen sairastumiseen [utu 17.2]

Suomen Kulttuurirahasto myönsi Turun yliopiston tutkimuksiin apurahoja yli 1,6 miljoonalla eurolla. Yhden suurimmista apurahoista saa FT Kari Kurppa syövän lääkehoitojen jälkeisen jäännöstaudin tutkimukseen. [14.2]

Vielä ehdit ilmoittautua Basic Immunology kurssille. Ilmoittautumislinkki ja lisää tietoa kurssista. [12.2]

Haettavana olevat apurahat ja avoimet paikat

Tällä hetkellä meillä ei ole avoimia apurahapaikkoja.

Lähetäthän tiedustelut mahdollisista harjoittelupaikoista suoraan ryhmänjohtajille.

Julkaisuarkisto

Täältä löydät Medicityssä työskentelevien tutkimusryhmien julkaisuja

 

Julkaisuarkisto 1995-2018

 

Julkaisut 2020

 

Julkaisut 2019

  1. Francisco R. López-Picón, Corresponding address, Anna K. Kirjavainen, Sarita Forsback, Jatta S. Takkinen, Dan Peters, Merja Haaparanta-Solin, Olof Solin. In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats. Theranostics 2019; 9(1):11-19. doi:10.7150/thno.29740

  2. Laurikainen H, Tuominen L, Tikka M, Merisaari H, Armio RL, Sormunen E, Borgan F, Veronese M, Howes O, Haaparanta-Solin M, Solin O, Hietala J; METSY group. Sex difference in brain CB1 receptor availability in man.Neuroimage. 2019;1;184:834-842. doi: 10.1016/j.neuroimage.2018.10.013.

  3. Krzyczmonik A, Keller T, López-Picón FR, Forsback S, Kirjavainen AK, Takkinen JS, Wasilewska A, Scheinin M, Haaparanta-Solin M, Sączewski F, Solin O. Radiosynthesis and Preclinical Evaluation of an α2A-Adrenoceptor Tracer Candidate, 6-[18F]Fluoro-marsanidine. Molecular Imaging and Biology. 2019;1. doi: 10.1007/s11307-019-01317-6.

  4. Viisanen T, Gazali AM, Ihantola EL, Ekman I, Näntö-Salonen K, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T. FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children. Frontiers in Immunology. 2019;22;10:19. doi: 10.3389/fimmu.2019.00019. eCollection 2019.

  5. Zeiner J, Loukovaara S, Losenkova K, Zuccarini M, Korhonen AM, Lehti K, Kauppinen A, Kaarniranta K, Müller CE, Jalkanen S, Yegutkin GG. Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage. Journal of Molecular Medicine (Berl). 2019;97(3):341-354. doi: 10.1007/s00109-018-01734-0.

  6. Tadayon S, Dunkel J, Takeda A, Halle O, Karikoski M, Gerke H, Rantakari P, Virtakoivu R, Pabst O, Salmi M, Hollmén M, Jalkanen S. Clever-1 contributes to lymphocyte entry into the spleen via the red pulp. Science Immunology. 2019;29;4(33). doi: 10.1126/sciimmunol.aat0297.

  7. Petar Petrov, Alexey V. Sarapulov, Lel Eöry, Cristina Scielzo, Lydia Scarfò, Jacqueline Smith, David W. Burt & Pieta K. Mattila. Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control.Scientific Reports. 2019; 9: 4155.

  8. Laurikainen H, Tuominen L, Tikka M, Merisaari H, Armio RL, Sormunen E, Borgan F, Veronese M, Howes O, Haaparanta-Solin M, Solin O, Hietala J; METSY group. Sex difference in brain CB1 receptor availability in man. Neuroimage. 2019 Jan 1;184:834-842. doi: 10.1016/j.neuroimage.2018.10.013.

  9. Viisanen T, Gazali AM, Ihantola EL, Ekman I, Näntö-Salonen K, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T. FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children. Front Immunol. 2019 Jan 22;10:19. doi: 10.3389/fimmu.2019.00019. eCollection 2019.

  10. Krzyczmonik A, Keller T, López-Picón FR, Forsback S, Kirjavainen AK, Takkinen JS, Wasilewska A, Scheinin M, Haaparanta-Solin M, Sączewski F, Solin O. Radiosynthesis and Preclinical Evaluation of an α2A-Adrenoceptor Tracer Candidate, 6-[18F]Fluoro-marsanidine. Mol Imaging Biol. 2019 Feb 1. doi: 10.1007/s11307-019-01317-6.

  11. Tadayon S, Dunkel J, Takeda A, Halle O, Karikoski M, Gerke H, Rantakari P, Virtakoivu R, Pabst O, Salmi M, Hollmén M, Jalkanen S. Clever-1 contributes to lymphocyte entry into the spleen via the red pulp. Science Immunology. 2019 Mar 29;4(33). doi: 10.1126/sciimmunol.aat0297.

  12. Zeiner J, Loukovaara S, Losenkova K, Zuccarini M, Korhonen AM, Lehti K, Kauppinen A, Kaarniranta K, Müller CE, Jalkanen S, Yegutkin GG. Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage. J Mol Med (Berl). 2019 Mar;97(3):341-354. doi: 10.1007/s00109-018-01734-0.

  13. Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA. Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors. Journal of Medicinal Chemistry. 2019 Apr 11;62(7):3677-3695.

  14. Petar Petrov, Alexey V. Sarapulov, Lel Eöry, Cristina Scielzo, Lydia Scarfò, Jacqueline Smith, David W. Burt & Pieta K. Mattila. Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control.Scientific Reports. 2019; 9: 4155.

  15. Marjaana Mäkinen  Eliisa Löyttyniemi  Maarit Koskinen  Mari Vähä-Mäkilä Heli Siljander  Mirja Nurmio  Juha Mykkänen  Suvi M Virtanen  Olli Simell  Heikki Hyöty Jorma Ilonen  Mikael Knip  Riitta Veijola  Jorma Toppari. Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes. The Journal of Clinical Endocrinology & Metabolism. Volume 104, Issue 6, June 2019, Pages 2277–2285.

  16. S. K. Vainio, A. M. Dickens, J. Tuisku, O. Eskola, O. Solin, E. Löyttyniemi, D. C. Anthony, J. O. Rinne, L. Airas and M. Haaparanta-Solin. Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation. EJNMMI Research. 2019 Apr 9:38.

  17. Laura Kähäri, Ruth Fair-Mäkelä, Kaisa Auvinen, Pia Rantakari, Sirpa Jalkanen, Johanna Ivaska, Marko Salmi. Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes. Journal of Clinical Investigation. 2019 Jun 24;130:3086-3102.

  18. Snellman A, Takkinen JS, López-Picón FR, Eskola O, Solin O, Rinne JO, Haaparanta-Solin M. Effect of genotype and age on cerebral [18F]FDG uptake varies between transgenic APPSwe-PS1dE9 and Tg2576 mouse models of Alzheimer's disease. Scientific Reports. 2019 Apr 5;9(1):5700.

  19. Motiani KK, Savolainen AM, Toivanen J, Eskelinen JJ, Yli-Karjanmaa M, Virtanen KA, Saunavaara V, Heiskanen MA, Parkkola R, Haaparanta-Solin M, Solin O, Savisto N, Löyttyniemi E, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC. Effects of short-term sprint interval and moderate-intensity continuous training on liver fat content, lipoprotein profile, and substrate uptake: a randomized trial. Journal of Applied Physiology (1985). 2019 Jun 1;126(6):1756-1768.

  20. Sanjay Bhattarai, Jan Pippel, Anne Meyer, Marianne Freundlieb, Constanze Schmies, Aliaa Abdelrahman, Amelie Fiene, Sang‐Yong Lee, Herbert Zimmermann, Ali El‐Tayeb, Gennady G. Yegutkin, Norbert Sträter, Christa E. Müller. X‐Ray Co‐Crystal Structure Guides the Way to Subnanomolar Competitive Ecto‐5′‐Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy. Advanced Therapeutics. 2019; Jul 31.

  21. Takeda A, Hollmén M, Dermadi D, Pan J, Brulois KF, Kaukonen R, Lönnberg T, Boström P, Koskivuo I, Irjala H, Miyasaka M, Salmi M, Butcher EC, Jalkanen S. Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils. Immunity. 2019 Aug 1. pii: S1074-7613(19)30297-3.

Yhteystiedot

MediCityn johtaja

Akateemikko Sirpa Jalkanen

Sihteeri

Katri Kulmala

Osoite

Turun yliopisto
Lääketieteellinen tiedekunta
Medicity
Biocity 4. krs 
Tykistökatu 6A
20520 Turku

Seuraa meitä Twitterissä ja LinkedInissä

Tutkimusryhmät

Elenius Klaus: ​Signaling of Receptor Tyrosine Kinases in Cancer and Development

Principal Investigator

Klaus Elenius
Professor of Medical Biochemistry,
Faculty of Medicine, University of Turku
MediCity Research Laboratories and Turku Center for Biotechnology
University of Turku and Åbo Akademi University
Cancer Research Laboratories, FICAN West

klaus.elenius [at] utu.fi

Description of Research

Our goal is to understand how receptor tyrosine kinases (RTK) regulate the pathogenesis of human diseases, such as cancer. This information is needed for the development of molecularly targeted therapies. To recognize aberrations of RTK signaling in diseased tissue our laboratory also works on the molecular mechanism by which RTKs control normal processes, such as embryonic development. The work mainly focuses on the ErbB family of RTKs. Our laboratory has contributed to the field by e.g. by characterizing novel RTK signaling mechanisms, by identifying novel ErbB4 isoforms, and by determining the role of ErbBs and their ligands in angiogenesis.

Current Topics

•    Screens for predictive RTK mutations
•    Novel RTK signaling mechanisms
•    Development of preclinical models for development novel RTK inhibitors
•    Sequencing of RTK inhibitor drug administration with cytotoxic agents
•    In vitro “basket trials” with ErbB inhibitor drugs
•    RTK signaling in angiogenesis and cardiovascular diseases
•    RTKs in pediatric malignancies
•    Biological role of novel ErbB4 isoforms in diseases and development

Group's Website

Heino Jyrki: Structure and Function of Collagen Receptor Integrins

Principal Investigator

Jyrki Heino
Scientific Director, BioCity Turku (BioCity Turku)
Professor, Biochemistry (Department of Biochemistry)
jyrki.heino [at] utu.fi

Description of Research

Our research group is studying the structure¬–function relationship of the collagen receptor integrins. The most important methods used include the production of recombinant protein domains, functional assays and mutations of the domains, bioinformatics as well as the expression and analysis of the full-length receptor proteins on cell surface. This has lead to a project aimed at development of small molecular inhibitors for collagen receptors. 
In addition to the structural work we are also interested in integrin signaling, especially atypical signaling mechanisms, including low avidity integrin–ligand interaction and signaling by nonactivated integrins. Most recently, we have studied the role of collagen receptor signaling in prostate cancer and the consequences of post-translational modifications, such as citrullination, of the integrin ligands in inflammation In these experiments we use the general methods of molecular cell biology, imaging by confocal microscopy and proteomics. In a separate project we have developed new software for quantitative bioimaging (BioImageXD).

Group Members

Jarmo Käpylä, Senior Scientist, Ph.D., Docent

Pekka Rappu, Postdoctoral Researcher

Johanna Jokinen, Postdoctoral Researcher

Elina Siljamäki, Postdoctoral Researcher

Anna-Brita Puranen, Doctoral Candidates

Marjaana Ojalill, Doctoral Candidates

Salli Keinänen, Doctoral Candidates

Maria Tuominen, Laboratory Technician

Noora Virtanen, Undergraduate Student

Ville Jokinen, Undergraduate Student

Hollmen Maija: Tumor Immunology and Immunotherapy

Principal Investigator

Maija Hollmen
Academy Research Fellow, Department of Clinical Medicine (Department of Clinical Medicine),
Adjunct Professor, MediCity Research Laboratory (Faculty of Medicine)
maijal [at] utu.fi

Description of Research

Our research exploits a unique scavenger receptor Clever-1, expressed on a subpopulation of immunosuppressive macrophages, to alleviate tumor related inflammation and develop Clever-1 as a companion therapeutic, diagnostic, and prognostic biomarker to treat and identify patients under immunosuppression. This involves the use of in vivo tumor models and sophisticated immunological assays with cutting-edge technology and state-of-the-art imaging combined with fresh human cancer patient material to elucidate the function of Clever-1 in controlling macrophage mediated local and systemic immune responses. Our results potentially have a high impact in understanding the mechanism of macrophage-mediated immunosuppression in cancer and promoting anti-Clever-1 immunotherapy into clinical trials where it may have benefits in comparison with currently available immune activating drugs.

Group's website / Group's Twitter

Hänninen Pekka: Laboratory of Biophysics

Principal Investigator

Pekka Hänninen
Professor, Institute of Biomedicine (Institute of Biomedicine),
Diagnostics and Bioimaging
pekka.e.hanninen [at] utu.fi

Description of Research

Laboratory of Biophysics develops instrumentation and methods for light microscopy, correlative multimodal microscopy and bio-analysis in general. The key application areas lie broadly within life-sciences research from basic research to applications but also in industrial processes of food technologies and industrial process waters are today on the agenda.
 
The group has recently developed new super-resolution techniques for 3D super-resolved tomography including software, super-resolution compatible nano-probes, super-resolution compatible in-vitro model for studies in bone-biology and most recently photoacoustic microscopy methods (PAM). In 2014 one of the former group members, Stefan Hell, was awarded the Nobel Prize in Chemistry for his work in the development of super-reselving microscopes, work that originated from our laboratory in the mid 90’s.
 
On the bioanalysis side, the group has developed a new type of chemical fingerprinting technique that has been applied from diagnostics of oral cancer to profiling of microbiota in the gut and analysis of bacteria in urine. The same technology has been demonstrated in several applications in the food industry and the technology has found its way also to production in the assessment of industrial process waters.
 
The group has been able to produce results that have lead both academic merits and into industrially exploited applications by a) licensing of the developed technologies to e.g. Leica Microsystems (2-photon microscopy, STED microscopy) and  b) through own startups (Arcdia International Oy and Aqsens Oy)

Group Members

Elnaz Fazelli, Doctoral Candidate (shared with groups of prof. J. Peltonen and prof. J. Eriksson/ÅA)
Elena Tcarenkova, Doctoral Candidate
 

Ilonen Jorma, Lempainen Johanna: Immunogenetics of Autoimmune Diseases

Principal Investigators

Jorma Ilonen
Professor, Institute of Biomedicine (Institute of Biomedicine)

jsilonen [at] utu.fi

Johanna Lempainen

Department of Pediatrics, Institute of Clinical Medicine,
University of TurkuUnit for Rare Diseases,
Turku University Hospital

nojoaa [at] utu.fi

Description of Research

These diseases result from interaction between genetic and environmental factors. The single most important gene region regulating immune response is the (MHC) major histocompatibility complex, in humans the HLA gene complex. Polymorphisms within genes in this region are largely responsible for the genetic susceptibility to many autoimmune diseases including type 1 diabetes, celiac disease, ankylosing spondylitis, rheumatoid arthritis and multiple sclerosis.

We have performed genetic studies in the series of the Finnish Pediatric Diabetes Register and genetic screening for disease susceptibility for recruitment of subjects to several type 1 diabetes associated follow-up projects including DIPP, TRIGR, PRODIA, FINDIA, DIABIMMUNE and TEDDY where children at genetic risk have been followed-up in attempt to identify environmental risk factors and understand pathogenetic mechanisms responsible for destruction of pancreatic ß-cells.

Results based on definition of both HLA and non-HLA gene polymorphisms as well as clinical characteristics suggest heterogeneity in pathogenetic mechanisms of type 1 diabetes and different interactions between genetic and environmental factors in various phases of the autoimmune process leading to clinical disease. 

Many of the mentioned studies have included trials attempting to prevent clinical type 1 diabetes either before the appearance of diabetes associated autoimmunity (primary prevention) or after appearance of diabetes associated autoantibodies (secondary prevention).

Group Members

Johanna Lempainen, Senior Researcher

Antti-Pekka Laine, Senior Researcher,

Minna Kiviniemi, Senior Researcher

Mari-Liis Mikk, Doctoral Candidate

Mia Karlsson, Laboratory Technician

Terhi Laakso, Laboratory Technician

Piia Nurmi, Laboratory Technician

Anne Suominen, Laboratory Technician

Ritva Suominen, Laboratory Technician
 

Jalkanen Sirpa: Cell Trafficking in Cancer and Inflammation

Principal Investigator

Sirpa Jalkanen
Professor, Academician
Institute of Biomedicine

sirpa.jalkanen [at] utu.fi

Description of Research

The overall goal of our research is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also, metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer.

Group's website

Li Jianwei: Molecular Systems Engineering

Principal Investigator

Jianwei Li

Senior Research Fellow, MediCity, PhD, Group Leader

jianwei.li [at] utu.fi

Description of Research

Molecular Systems Engineering is an emerging field by understanding the fundementals of molecular properties and dynamics in synthetic complex systems, and exploring sophisticated functions for advanced applications in biomedicine, materials and energy. Our laboratory uses the tools of dynamic combinatorial chemistry (DCC), supramolecular chemistry and computer chemistry to fabricate the framework of complex chemical systems, investigates the self-assembly in such systems and uncovers the working principles at molecular level behind them. We have learned that self-assembly can not only direct the formation of beautiful and intriguing structures i.e. catenanes and “Russian-doll”-like supramolecular architectures, but also promote the molecules to make copies of themselves as the living matters in nature. Currently we are trying to extend the board of DCC into the fields of materials science, enzymology and biology by three lines of research: 1) dynamic combinatorial biomaterials for controlling cell behaviors; 2) enzyme-directed DCC; and 3) DCC in vivo.

Group's website

Kurppa Kari: Cancer Drug Resistance

​​​Principal Investigator

Kari J. Kurppa, Senior Researcher, Institute of Biomedicine

kjkurp@utu.fi

Description of Research

Our aim is to understand the means cancer cells use to develop resistance to cancer therapies. Our special focus are the mechanisms that enable the establishment of minimal residual disease, or govern the maintenance of residual tumors following targeted cancer therapy. The overarching goal of our research is to develop rational combination strategies that will extend the long-term efficacy of clinically used cancer therapies.

While targeted therapy has transformed the treatment of cancer, the long-term efficacy of these strategies is hampered by acquired drug resistance. In many cases, clinical drug resistance is preceded by minimal residual disease (MRD) state, where residual tumors stay dormant for an extended period of time. Emerging evidence indicates that the establishment of MRD is mainly regulated by non-genetic mechanisms, as cancer cells adapt to treatment by acquiring new phenotypic states that no longer depend on the targeted oncogene. These slow-cycling drug tolerant cells can regain proliferative state upon drug withdrawal or acquisition of additional resistance mechanisms, and as such serve as a reservoir of dormant cells capable of re-initiating the growth of a drug resistant tumor. Understanding the mechanisms underlying the establishment or maintenance of minimal residual disease would enable the development of rational combination strategies aimed to prevent or limit residual disease, leading to prolonged survival of cancer patients.

Group's website

Mattila Pieta: ​Lymphocyte Cytoskeleton

Principal Investigator

Pieta Mattila
Academy Research Fellow, Institute of Biomedicine
pieta.mattila [at] utu.fi

Description of Research

Our research group studies the regulation of lymphocyte activation with a special focus on the control provided by the cellular cytoskeleton. We integrate immunological and cell biological methods including advanced light microscopy, biochemistry, and cellular and in vivo models, to gain novel understanding on the function and regulation of the immune system.

Group's website / Twitter

Nakamura Miho: Engineering of Bone to Prevent Osteoporosis

Principal Investigator

Miho Nakamura

Adjunct Professor, Department of Clinical Medicine, Senior Researcher at TCSM, Institute of Biomedicine

mihnak@utu.fi

Description of Research

Main goal of our research is to find a solution for bone diseases in elderly population, such as osteoarthritis and osteoporosis. Our research is aiming at multidisciplinary collaborations between medicine, cell biology and materials science.

My current research interest includes:

  • Bio-inspired biomaterials to enhance bone regeneration through the manipulation of bone cells (osteoblasts, osteocytes and osteoclasts)
  • New parameters for the evaluation of bone quality using knowledge of materials science
  • Mechanism of osteolysis in aseptic loosening
  • Engineering of bone to prevent osteoporosis

Keywords: Biomaterials, Tissue Engineering, Bone regeneration, Osteoblasts, Osteocytes, Osteoclasts, Osteolysis

Group members

Uruj Sarwar, Doctoral Candidate

Jorgan Sobrepena, Master Student

Leire Bergara Muguruza, Undergraduate Student

We are looking for students (undergraduates, masters, Ph.D. candidates all welcome)! Please feel free to contact/ visit us.

Selected Publications

Tuukkanen J, Nakamura M. Hydroxyapatite as a nanomaterial for tissue engineering and drug therapy. Curr Pharm Design, 2017: 23(26), 3786-3793.

Nakamura M, Hori N, Ando H, Namba S, Toyama T, Nishimiya N, Yamashita K. Surface Free Energy Predominates in Cell Adhesion to Hydroxyapatite through Wettability. Mater Sci Eng C 2016: 62, 283-292.

Nakamura M, Hiratai R, Hentunen T, Salonen J, Yamashita K. Hydroxyapatite with High Carbonate Substitutions Promotes Osteoclast Resorption through Osteocyte-like Cells. ACS Biomater Sci Eng 2016: 2 (2), 259-267.

Nakamura M, Hentunen T, Salonen J, Nagai A, Yamashita K. Characterization of bone mineral-resembling biomaterials for optimizing human osteoclast differentiation and resorption. J Biomed Mater Res A, 2013: 101A (11), 3141-3151.

Nakamura M, Soya T, Hiratai R, Nagai A, Hashimoto K, Morita I, Yamashita K. Endothelial cell migration and morphogenesis on silk fibroin scaffolds including hydroxyapatite electret. J Biomed Mater Res A 2012: 100A, 969-977.

PET Project

Principal Investigators

Merja Haaparanta-Solin Adjunct Professor,
Senior Researcher, Head of Preclinical Imaging,
Turku PET Centre

merja.haaparanta-solin [at] utu.fi

Tove Grönroos, Adjunct Professor,
Senior Researcher, Manager of Preclinical Metabolic Research,
Turku PET Centre 

tovgro [at] utu.fi

Fracisco López-Picón, Senior Researcher and Manager of Preclinical Neuroscience Imaging

francisco.lopez [at] utu.fi

Description of Research

The general goals of the Preclinical and translational research unit are a) to evaluate and develop new PET tracers, b) to be a bridge between basic and clinical research in all areas where the PET Centre is involved, c) to be a reference core facility for basic biomedical research, d) to collaborate with pharmaceutical companies in drug development, and e) to be an important training centre for techniques related to animal imaging.

The preclinical unit actively participates in the novel radiotracer development at the Turku PET Centre including tissue penetration, target validation and metabolite analysis in experimental animals, and metabolism in the first in man studies. We collaborate extensively with the Central Animal Laboratory (CAL), the Turku Centre for disease Models (TCDM), and Auria Biobank for our research with animal models and tissues.

The preclinical unit works in numerous research projects. Among these projects are specific preclinical and basic science projects, internal collaborations with the Radiopharmaceutical chemistry unit and clinicians from different units. In addition, we have many collaboration projects with local, national, and international academic and commercial partners.

Cardiac and metabolic research
Most preclinical (nonclinical) work is done using small animals (mice, rats) whose physiology is dissimilar to human and, therefore, also the translation of imaging is challenging. The aim is to develop and validate pig models for coronary heart disease and heart failure. This work is done jointly with teams in Osaka, Canada and Kuopio. These models enable the investigation of disease mechanisms at the cellular level parallel with testing and the validation of new tracers and imaging methods. 

Oncology
The oncology group aims to improve diagnostic imaging by developing new PET tracers, evaluating their usage in different experimental settings and to translate and introduce research findings into the clinic. The research focuses on imaging the tumour microenvironment by targeting specific proteins and genes, or general processes that occurs in tumours and are important in treatment planning and therapy resistance. Proliferation, apoptosis, angiogenesis, oxygen metabolism, inflammatory response and oncogene expression is of central importance in development of novel biologically targeted agents and adaptive radiotherapy.

Neuroscience
The preclinical research in neuroscience will continue the current work in neurodegeneration, and neuroinflammation, and will expand into new research in neuropsychiatry in collaboration with radiochemistry and clinicians. The focus will mainly be on the following topics:

1) Development of novel radiotracers for neuroscience will focus on the detection of tau tangles, neuroinflammation, norepinephrine transporter and synaptic function.

2) Identification of novel mechanism of disease in neurodegeneration, neuroinflammation and psychiatric diseases, and in the identification of novel targets for tracer development and drug targeting.

Pet Center's website / Twitter

Salmi Marko: Leukocyte Traffic and the Immune Response

Principal Investigator

Marko Salmi, MD, PhD
Professor of Molecular Medicine,
Medicity Research Laboratory and
Institute of Biomedicine

e-mail: marko.salmi@utu.fi
Tel: +358-50-3385678

Description of Research

Leukocyte migration from the blood and lymph into tissues is critical for generation of normal immune responses. Abnormal leukocyte traffic contributes to the pathogenesis of all inflammatory diseases and several other diseases, such as cancer. We study the molecular mechanisms and functional implications of leukocyte migration in the body. We have identified several new adhesion molecules (e.g. vascular adhesion protein-1 (VAP-1), CD73, stabilin-1, plasmalemma vesicle associated protein (Plvap)) on blood and lymphatic vessels and leukocytes, which mediate different steps of leukocyte extravasation from the vessels.

We have also studied the therapeutic value of modulating the function of these and other adhesion receptors in inflammation and cancer. We also elucidate the differentiation pathways of monocytes/macrophages by studying the role of the developmental origin and tissue niche for their plasticity and functions. In addition, we are interested in defining the routes by which antigens enter the lymph node parenchyma via the lymphatic vasculature during the triggering of immune responses. As a separate line of research, we have analyzed the value of adhesion molecules and cytokines as biomarkers of disease in population and patient cohorts.

Group's website

 

 

Savolainen Johannes: Allergology Research

​​​Principal Investigator

Johannes Savolainen

Professor, Pulmonary Diseases and Clinical Allergology (Department of Clinical Medicine)

johsav@utu.fi

Description of Research

Research project titles

    A Novel Glycocluster Molecule for treatment of Allergy and Cancer
    Mechanisms of Specific Oral Tolerance Induction (SOTI) in Food Allergic Children

The primary objective of our interdisciplinary research is to develop new glycocluster molecules to be used in microbial, allergy and cancer vaccines. The secondary object is to explore the mechanisms of action of the glycoclusters. Immunostimulatory beta-1,2-linked mannoside cluster molecules are structurally optimized and derivatized, including new covalently linked bioconjugates and fluorine-labeled targets. Advanced NMRspectroscopic methods are applied for conformational and lectin-binding studies. Immunostimulatory properties are investigated in vitro and in vivo in murine models of allergic asthma, chronic allergic inflammation and melanoma tumors. As a result, fundamental understanding relevant to application of glycobiology to immunotherapy will be achieved.
Members of the research group

Group Members

Leena Kavén-Honka, laboratory technician

Selected Publications

Savolainen J, Ranta K, Mukherjee C, Leino R. Immunostimulatory Compounds and Uses Thereof, Finn. Pat. Appl. FI20115631 (to University of Turku and Åbo Akademi University); U.S. Pat Appl. 61/499,229 (Filed June 21, 2011); Int. Appl. PCT/FI/2012/050650 (Filed June 21, 2012); U.S. Pat. 9221861 (Issued Dec. 29,
2015).

Mukherjee C, Ranta K, Savolainen J, Leino R. Synthesis and Immunological Screening of ß-Linked Monoand Divalent Mannosides. Eur J Org Chem, 2012; 2957-2968.

Linnamaa P, Nieminen K, Koulu L, Tuomasjukka S, Kallio H, Yang B, Tahvonen R, Savolainen J. Proinflammatory and Th2 type cytokine responses in PBMC in infants are associated with parental smoking. Clin Exp Allergy, 2012;42:1472-1478.

Mukherjee C, Mäkinen K, Savolainen J, Leino R. Chemistry and biology of oligovalent β-(1,2)-linked oligomannosides: New insights into carbohydrate based adjuvants in immunotherapy. Chem-Eur J. 2013, 19:7961-74.

Rahkila J, Panchadhayee R, Ardá A, Jiménez-Barbero J, Savolainen J, Leino R. Acetylated Trivalent Mannobioses: Chemical Modification, Structural Elucidation, and Biological Evaluation. ChemMedChem. 2016;11:562-74.

Toppari Jorma: Insulin-Dependent Diabetes

Principal Investigator

Jorma Toppari
Professor, Institute of Biomedicine
jortop [at] utu.fi

Description of Research

DIPP study has screened more than 200 000 newborns for genetic risk of T1D and about 17 000 children have participated in the follow-up that includes regular visits, interviews and collection of various kinds of biological samples until the age of 15 or diagnosis of T1D. The recruitment started in 1994 and is still continuing constituting a data and sample repository of dynamic birth cohort that includes a large number of children at different stages of the disease process.

DIPP study welcomes proposals for collaboration studies to facilitate the international research efforts aiming at identification of causes of T1D and developing prevention and better treatments for the disease. The collaboration studies can include various kinds of studies covering e.g. analyses of the clinical samples and/or the data collected in the DIPP study as well as clinical trials.

Group Members

Satu Ruohonen, Medical Laboratory Technologist

Minna Romo, Medical Laboratory Technologist

Zhian Othmani, Medical Laboratory Technologist 

Elina Mäntymäki, Medical Laboratory Technologist

Mari Vähä-Mäkilä, Senior Researcher

Marjaana Mäkinen, Doctoral Student

Group's website

Zavialov Anton: Joint Biotechnology Laboratory

Principal Investigator

Anton Zavialov
Senior Research Fellow, Joint Biotechnology Laboratory (JBL)
anton.zavialov [at] utu.fi

Description of Research

We work in the field of structural biology and structure-based drug design. Our main methods are x-ray crystallography and cryo-electron microscopy. The main focus of our research is the unraveling of molecular mechanisms governing the interplay between microbial pathogens and their hosts, and the exploitation of these finding in medicine. We are particularly interested in host-pathogen interactions during the early steps of infection: bacterial attachment and biofilm formation mediated by fimbrial adhesins and host tissue invasion mediated by the Type III secretion system. Blocking these steps could prevent infections caused by antibiotic-resistant pathogens. Another line of our research explores the intricate cell signaling mechanism of the novel growth factor-enzyme, adenosine deaminase type 2 (ADA2). This study paves the way for the development of novel means to treat blood cancers and vascular disorders, including a genetic disease called deficiency of ADA2 (DADA2). In addition, we develop a novel ADA-based immuno-oncological therapy of advanced cancers.

Group Members

Minna Tuittila, Postdoctoral Researcher

Sari Paavilainen, Senior Researcher

Henri Malmi, Doctoral Candidate

Maksym Skaldin, Doctoral Candidate

Vladimir Zav’yalov, Visiting Professor

Selected publications

Skaldin M, Tuittila M, Zavialov And. V & Zavialov Ant. V (2018) Secreted bacterial adenosine deaminase is an evolutionary precursor of adenosine deaminase growth factor. Molecular Biology and Evolution, 35:2851-2861.

Pakharukova N, McKenna S, Tuittila M, Paavilainen S, Parilova O., Malmi H, Matthews S. & Zavialov AV (2018) Archaic and alternative chaperones preserve pilin folding energy by providing incomplete structural information. Journal of Biological Chemistry, 293(44):17070-17080.

Pakharukova N, Tuittila M, Paavilainen S, Malmi H, Parilova O, Teneberg S, Knight S & Zavialov AV‡ (2018) Structural basis for Acinetobacter baumannii biofilm formation. Proc Natl Acad Sci U S A 115, 5558-5563

Gurung J, Amer A, Francis MK, Costa TRD, Chen S, Zavialov AV & Francis MS (2018) Heterologous Complementation Studies With the YscX and YscY Protein Families Reveals a Specificity for Yersinia pseudotuberculosis Type III Secretion. Frontiers in cellular and infection microbiology 8, 80.

Pakharukova N, Roy SP, Tuttila MT, Paavilanen S, Ingars A-K, Skaldin M, Lamminmäki U, Härt T, Teneberg S. & Zavialov AV (2016). Structural basis for Myf and Psa fimbriae-mediated tropism of pathogenic strains of Yersinia for host tissues. Molecular Microbiology, 102, 593–610.

Pakharukova N., Garnett G, Tuittila MT, Paavilainen S., Diallo M, Xu Y., Matthews S. and Zavialov AV (2015) Structural insight into archaic and alternative chaperone-usher pathways reveals non-classical mechanism of pilus biogenesis. PLoS Pathogens, 11:e1005269.

Amer A, Gurung J, Costa T, Zavialov AV, Forsberg Å  & Francis M (2015) YopN and TyeA hydrophobic contacts required for regulating Ysc-Yop type III secretion activity by Yersinia pseudotuberculosis. Frontiers in cellular and infection microbiology, 6:66.

Berry A, Yang Y, Pakharukova N, Garnett J, Lee W, Cota E, Marchant J, Roy S, Tuittila M, Liu B, Inman K, Ruiz-Perez F, Mandomando I, Nataro J, Zavialov AV and Matthews S (2014) Structural insight into host recognition by aggregative adherence fimbriae of enteroaggregative Escherichia coli. PLoS Pathogens, 10, e1004404

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